[苯并呋喃-苯并西平治疗大鼠假瘤性子宫反应]。

Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles Pub Date : 1980-09-29

G Barchewitz, F Binon, A Cier, H Tuchmann-Duplessis

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引用次数: 0

摘要

口服5-(3- dimsamuthylamino propyliden)-苯并ofuro [2,3-c] benzoxepin-1，可拮抗几种生物胺，在大鼠中具有轻微镇静作用，并具有内分泌特性，可诱导2%至16%的动物出现局部子宫间质病变。细胞学图像提示肿瘤发生。事实上，这些病变代表了非肿瘤反应性增生，由于激素刺激导致核异常。

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[Pseudotumoral uterine reaction in the rat treated with a benzofuro-benzoxepin].

When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.

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Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles

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