妊娠对大鼠门静脉自发收缩和钡反应性的影响。

J L Hart
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引用次数: 0

摘要

比较未怀孕大鼠和怀孕1、2、3周大鼠门静脉的自发活动和BaCl2反应性。血管悬浮在37℃的含氧克雷布斯溶液中,记录等长张力。平衡60-90分钟后,测量峰值等距张力、收缩频率和持续时间。然后测定对BaCl2累积添加量的响应。妊娠大鼠与非妊娠大鼠静脉初始等距张力发育无显著差异。然而,宫缩的频率在怀孕的三个阶段都减少了,主要宫缩的持续时间增加了。钡引起剂量相关的张力增加和所有血管收缩频率降低。然而,所有怀孕大鼠的静脉张力的最大增幅都明显低于未怀孕大鼠,而钡诱导的收缩频率的下降仅在妊娠3周时显著大于未怀孕大鼠。因此,妊娠降低了整个妊娠期间大鼠门静脉自发收缩的频率,并抑制了钡诱导的张力发展的增加。静脉平滑肌活动的这些变化类似于妊娠引起的动脉、子宫和胃肠道平滑肌的变化,可能依赖于妊娠期间黄体酮升高对平滑肌的抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of pregnancy on spontaneous contraction and barium responsiveness of the rat portal vein.

Spontaneous activity and BaCl2 responsiveness of portal veins from non-pregnant and from 1-, 2-, and 3-week pregnant rats were compared. Isometric tension was recorded from vessels suspended in oxygenated, 37 degrees C Krebs solution. After 60-90 min equilibration, peak isometric tension, contraction frequency, and duration were measured. Then responses to cumulative additions of BaCl2 were determined. Initial isometric tension development of veins from pregnant rats was not significantly different from that of the non-pregnant rats. However, the frequency of contractions was reduced at all three stages of pregnancy and the duration of major contractions was increased. Barium caused dose-related increases in tension and reduced contraction frequencies of all vessels. Maximum increases in tension of veins from all pregnant rats were significantly less, however, than those of veins from non-pregnant rats, while barium-induced decreases in contraction frequencies were significantly greater only at 3-weeks gestation. Thus, pregnancy decreases the frequency of the spontaneous contractions of the rat portal vein throughout pregnancy, and inhibits the barium-induced increases in tension development. These changes in venous smooth muscle activity are similar to pregnancy-induced changes that have been reported to occur in arterial, uterine, and gastrointestinal smooth muscle, and may be dependent on a general smooth muscle inhibitory effect of elevated progesterone during pregnancy.

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