动脉内膜切除术后肝素逆转对动脉粥样硬化动物模型的影响。

Bulletin of clinical neurosciences Pub Date : 1984-01-01
S L Giannotta, S K Hirtz, S Hyman
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引用次数: 0

摘要

通过球囊损伤和致动脉粥样硬化饮食在新西兰白兔的主动脉中诱导局灶性动脉粥样硬化斑块。在全麻和全身肝素化治疗下,在手术显微镜下行动脉内膜切除术。分别于动脉内膜切除术后5、10、20和60分钟处死动物,对手术后的主动脉段进行灌注,并用扫描电镜检查。每个节段与正常非动脉粥样硬化兔动脉内膜切除的类似节段进行比较。血栓形成包括聚集的血小板、红细胞和纤维蛋白,在动脉粥样硬化段更为明显。另外10只动脉粥样硬化兔子接受了相同的治疗,只是在动脉内膜切除术后5分钟用硫酸鱼精蛋白逆转肝素。当将这些标本与没有肝素逆转的类似动脉粥样硬化组进行比较时,很明显,在“逆转”段发生了巨大的血栓形成过程。这项研究表明动脉粥样硬化可能改变血管手术后的血栓形成,动脉内膜切除术后早期肝素逆转应谨慎看待。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of heparin reversal following endarterectomy in an atherosclerotic animal model.

A focal atherosclerotic plaque was induced in the aortas of New Zealand White female rabbits by a balloon injury and an atherogenic diet. Under general anesthesia and systemic heparinization, endarterectomy was performed using the operating microscope. Animals were sacrificed at 5, 10, 20, and 60 min following the endarterectomy and operated aortic segments were perfused and examined using scanning electron microscopy. Each segment was compared to a similar segment of endarterectomized aorta from a normal, nonatherosclerotic rabbit. Thrombus formation including aggregated platelets, red cells, and fibrin was found to be more pronounced in the atherosclerotic segments. Ten more atherosclerotic rabbits underwent identical procedures except that heparin was reversed using protamine sulfate 5 min following the endarterectomy. When these specimens were compared to a similar atherosclerotic group without heparin reversal, it was evident that a tremendous thrombogenic process had taken place in the "reversed" segments. This study suggests that atherosclerosis may alter thrombogenesis following an operative vascular procedure and that early reversal of heparin following an endarterectomy should be viewed with caution.

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