从蕨菜中分离出的ptaquilo甙对大鼠的致癌性。

Gan Pub Date : 1984-10-01

I Hirono, S Aiso, T Yamaji, H Mori, K Yamada, H Niwa, M Ojika, K Wakamatsu, H Kigoshi, K Niiyama

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引用次数: 0

摘要

存在于蕨类植物中的致癌物的性质尚未被阐明。最近，我们成功地从蕨菜中分离出一种新型的去甲倍半萜苷类化合物ptaquiloside。研究表明，蕨类植物的致癌性主要体现在叶甲苷上。雌性Sprague-Dawley大鼠口服本品可诱发乳腺癌和多种回肠肿瘤，发生率高。

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Carcinogenicity in rats of ptaquiloside isolated from bracken.

The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.

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Gan

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