细胞嵌合小鼠自发性多发性乳腺肿瘤的克隆起源。

Gan Pub Date : 1984-09-01

K Tanaka, A Ootsuyama, H Tanooka

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引用次数: 0

摘要

研究小鼠自发性多发性乳腺肿瘤的克隆起源。为此，我们构建了具有高自发性乳腺肿瘤发生率的磷酸甘油酸激酶(PGK)-1同工酶X染色体失活嵌合体的杂交雌性小鼠(PGK -1b/ PGK -1a) F1[SHN(PGK -1b) X C3H/He (PGK -1a)]。马赛克小鼠的45个乳腺肿瘤中有37个(82%)具有单一表型的PGK，表明单克隆起源。在这些小鼠中形成的多发性乳腺肿瘤在PGK类型上各不相同，表明独立的细胞起源。

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Clonal origin of spontaneous multiple mammary tumors in mice with cellular mosaicism.

The clonal origin of spontaneous multiple mammary tumors in mice was examined. For this purpose, hybrid female mice (Pgk-1b/Pgk-1a), F1[SHN(Pgk-1b) X C3H/He (Pgk-1a)], with X-chromosome inactivation mosaicism with regard to the phosphoglycerate kinase (PGK)-1 isozyme together with a high incidence of spontaneous mammary tumors were constructed. Thirty-seven of 45 mammary tumors (82%) in mosaic mice had a single phenotype of PGK, indicating monoclonal origin. The multiple mammary tumors formed in these mice varied in PGK type, indicating independent cellular origins.

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Gan

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