肝素抗凝治疗马绞痛。

Modern veterinary practice Pub Date : 1984-08-01
S G Duncan, S M Reed
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引用次数: 0

摘要

在患有大肠疾病的马中,那些有循环内毒素但没有证据表明止血改变的马预后良好。那些循环内毒素和证据改变止血(纤维蛋白降解产物)预后差。门静脉输注内毒素超过24小时会引起蹄部不适,表现为体重转移和4脚站立在一起,以及蹄温下降。临床症状在开始输注30分钟内出现,持续输注4小时内消退。长期肝素治疗导致红细胞快速消耗,但没有检测到出血。肝素治疗应在绞痛手术开始前开始。凝血监测与活化部分凝血活酶时间。肝素最初应静脉滴注,然后SC或静脉内注射,不应静脉滴注。硫酸鱼精蛋白可逆转肝素的抗凝作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Heparin anticoagulant therapy in equine colic.

In horses with large bowel disease, those with circulating endotoxins but no evidence of altered hemostasis had a good prognosis for survival. Those with circulating endotoxins and evidence of altered hemostasis (fibrin degradation products) had a poor prognosis. Portal vein infusion of endotoxins over 24 hours caused hoof discomfort, evidenced by shifting of weight and standing with all 4 feet together, and a decreased hoof temperature. Clinical signs appeared within 30 minutes of initiation of infusion and subsided within 4 hours despite continued infusion. Long-term heparin therapy results in rapid depletion of RBC but no detectable bleeding. Heparin therapy should be initiated before colic surgery is begun. Coagulation is monitored with the activated partial thromboplastin time. Heparin should initially be given IV, followed by SC or intrafat injections, and should never be given IM. The anticoagulative effects of heparin can be reversed with protamine sulfate.

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