{"title":"血红素对二硝基芘诱导的中国仓鼠V79细胞诱变的抑制作用。","authors":"Y Katoh, S Takayama, K Shudo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The inhibitory effects of hemin on the mutagenic activities of 1,3-, 1,6- and 1,8-dinitropyrenes (1,3-,1,6- and 1,8-DNPs) were investigated in Chinese hamster V79 cells. Mutant cells were selected on the basis of their resistance to ouabain. Hemin itself did not have any cytotoxic effect on Chinese hamster V79 cells, and did not induce mutations when added at a concentration of 10 micrograms/ml. The mutagenic activities of 1,3-, 1,6- and 1,8-DNPs were inhibited dose-dependently by hemin and were reduced 91.7%, 95.7% and 94.7%, respectively, by the highest concentration of hemin tested (10 micrograms/ml).</p>","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 7","pages":"574-7"},"PeriodicalIF":0.0000,"publicationDate":"1984-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhibition by hemin of dinitropyrene-induced mutagenesis in Chinese hamster V79 cells.\",\"authors\":\"Y Katoh, S Takayama, K Shudo\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The inhibitory effects of hemin on the mutagenic activities of 1,3-, 1,6- and 1,8-dinitropyrenes (1,3-,1,6- and 1,8-DNPs) were investigated in Chinese hamster V79 cells. Mutant cells were selected on the basis of their resistance to ouabain. Hemin itself did not have any cytotoxic effect on Chinese hamster V79 cells, and did not induce mutations when added at a concentration of 10 micrograms/ml. The mutagenic activities of 1,3-, 1,6- and 1,8-DNPs were inhibited dose-dependently by hemin and were reduced 91.7%, 95.7% and 94.7%, respectively, by the highest concentration of hemin tested (10 micrograms/ml).</p>\",\"PeriodicalId\":12660,\"journal\":{\"name\":\"Gan\",\"volume\":\"75 7\",\"pages\":\"574-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gan","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在中国仓鼠V79细胞中研究了血红素对1,3-、1,6-和1,8-二硝基芘(1,3-、1,6-和1,8- dnps)致突变活性的抑制作用。根据突变细胞对瓦巴因的抗性选择突变细胞。Hemin本身对中国仓鼠V79细胞无细胞毒作用，添加浓度为10微克/毫升时不诱导突变。hemin对1,3-、1,6-和1,8- dnps的诱变活性有剂量依赖性的抑制作用，当hemin浓度最高(10 μ g /ml)时，其诱变活性分别降低91.7%、95.7%和94.7%。
Inhibition by hemin of dinitropyrene-induced mutagenesis in Chinese hamster V79 cells.
The inhibitory effects of hemin on the mutagenic activities of 1,3-, 1,6- and 1,8-dinitropyrenes (1,3-,1,6- and 1,8-DNPs) were investigated in Chinese hamster V79 cells. Mutant cells were selected on the basis of their resistance to ouabain. Hemin itself did not have any cytotoxic effect on Chinese hamster V79 cells, and did not induce mutations when added at a concentration of 10 micrograms/ml. The mutagenic activities of 1,3-, 1,6- and 1,8-DNPs were inhibited dose-dependently by hemin and were reduced 91.7%, 95.7% and 94.7%, respectively, by the highest concentration of hemin tested (10 micrograms/ml).
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