在过氧化氢和铁离子存在下，多酚和氨基酚在C-8位羟基化脱氧鸟苷。

Gan Pub Date : 1984-07-01

H Kasai, S Nishimura

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引用次数: 0

摘要

在过氧化氢和铁离子存在下，测试了各种多酚和氨基酚与脱氧鸟苷和DNA的反应性。这些处理能有效地使脱氧鸟苷在C-8位羟基化。在DNA的情况下，除了鸟嘌呤残基的羟基化外，还观察到链断裂。

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Hydroxylation of deoxy guanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion.

Various polyphenols and aminophenols were tested for reactivity with deoxyguanosine and DNA in the presence of hydrogen peroxide and ferric ion. Deoxyguanosine was efficiently hydroxylated at the C-8 position by these treatments. In the case of DNA, strand scission was observed in addition to the hydroxylation of guanine residues.

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Gan

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