莫里斯肝癌中c-myc基因的扩增和过表达。

Gan Pub Date : 1984-06-01

K Hayashi, R Makino, T Sugimura

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引用次数: 0

摘要

Morris肝癌7794A被发现其c-myc基因扩增5- 10倍。在研究的所有三种肝癌中(莫里斯肝癌5123D、7136A和7794A)均观察到c-myc的过表达，尽管在前两例中c-myc基因未扩增。c-myc的过度表达或失调似乎是与肝癌相关的普遍现象。

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Amplification and over-expression of the c-myc gene in Morris hepatomas.

Morris hepatoma 7794A was found to have its c-myc gene amplified 5- to 10-fold. The over-expression of c-myc was observed in all three hepatomas studied (Morris hepatomas 5123D, 7136A and 7794A), although in the first two instances the c-myc genes were not amplified. Over-expression or deregulation of c-myc seems to be a general phenomenon associated with hepatoma.

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Gan

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