奥替普拉茨与吡喹酮治疗加蓬尿路血吸虫病的比较试验。

Tropenmedizin und Parasitologie Pub Date : 1984-06-01
G D Burchard, P Kern, R Baltes, M Dietrich
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引用次数: 0

摘要

以1 × 25mg /kg体重、1 × 35mg /kg体重和2 × 20mg /kg体重的奥替普拉对加蓬尿路血吸虫病患儿的杀虫效果进行了研究,并与2 × 30mg /kg体重的吡喹酮进行了比较。本研究对165例患者进行研究,并在治疗后6周和12周进行随访调查。当剂量为1 × 25 mg/kg体重和1 × 35 mg/kg体重时,Oltipraz的疗效低于吡喹酮。然而,奥替普拉2 × 20 mg/kg体重与吡喹酮2 × 30 mg/kg体重相当。79%的奥替普拉患者和81%的吡喹酮患者获得了寄生虫学治愈率。两组的副作用均不显著。因此,oltipraz和吡喹酮可以达到同样的寄生虫治疗效果,但oltipraz的剂量较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon.

The efficacy of oltipraz as a schistosomicidal drug was investigated in Gabonese children suffering from urinary schistosomiasis in the dosages of 1 X 25 mg/kg body weight, 1 X 35 mg/kg body weight, and 2 X 20 mg/kg body weight and compared to praziquantel, 2 X 30 mg/kg body weight. The study was undertaken in 165 patients, and follow-up investigations were carried out 6 weeks and 12 weeks after treatment. Oltipraz showed less efficacy compared to praziquantel when dosages of 1 X 25 and 1 X 35 mg/kg body weight were given. However, oltipraz 2 X 20 mg/kg body weight was equivalent to praziquantel 2 X 30 mg/kg body weight. Parasitological cure was obtained in 79% of patients treated by oltipraz and 81% of patients treated by praziquantel. Side effects were insignificant in both treatment groups. Thus, the same parasitological cure could be achieved by oltipraz as well as by praziquantel, but with a lower dosage of oltipraz.

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