副氯苯丙氨酸对安定戒断后异常行为发生率的影响

Progress in neuro-psychopharmacology Pub Date : 1981-01-01 DOI:10.1016/0364-7722(81)90094-1

Tsutomu Suzuki , Toshio Yoshii , Saizo Yanaura , Ryuji Fukumori , Tetsuo Satoh , Haruo Kitagawa

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引用次数: 3

摘要

1.1. 通过在饮食中增加地西泮的剂量，使大鼠对地西泮产生依赖。在停用地西泮时，给动物注射副氯苯丙氨酸(PCPA)，一种有效的5-羟色胺(5-HT)消耗剂，或相应的载药。停用地西泮后，pppa处理的动物表现出攻击、易怒、发声、肌肉僵硬等异常行为。相比之下，对照组动物的行为几乎没有变化。这些结果表明，PCPA对大脑5-羟色胺的消耗会增强地西泮戒断症状。

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Effect of parachlorophenylalanine on the incidence of abnormal behaviors observed following diazepam withdrawal

1.
1. Rats were rendered dependent on diazepam by administrating escalating dosages of diazepam in diet.
2.
2. At the time of diazepam withdrawal, the animals were treated with parachlorophenylalanine (PCPA), a potent serotonin (5-HT) depleter, or the corresponding vehicle.
3.
3. After diazepam withdrawal, PCPA-treated animals showed abnormal behaviors, such as aggression, irritability, vocalization and muscular rigidity.
4.
4. In contrast, little or no changes in behavior were observed in control animals.
5.
5. These results suggest that depletion of brain 5-HT by PCPA potentiates diazepam withdrawal signs.

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Progress in neuro-psychopharmacology

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