肌肉注射舒芬太尼和吗啡。清醒人的副作用比较[作者译]。

Anesthesie, analgesie, reanimation Pub Date : 1981-01-01
M Cathelin, R Vignes, A Malki, P Viars
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引用次数: 0

摘要

为了本研究的目的,有意识的男性通过肌肉内注射以增加剂量(0,00015,0,0003,0,0006 mg/kg)给药,并将结果与在相同条件下使用吗啡(0,100,0,150,0,200 mg/kg)获得的结果进行比较。服用这两种药物会引起同样的副作用。呼吸速率衰竭的速度与注射等量吗啡后观察到的一样快。与止痛的情况一样,呼吸速率下降所需的时间和持续时间用磺胺太尼比用吗啡要短。在任何情况下,他们的持久性太大,不能认为是一个药物的短期效果。舒芬太尼对心律(心动过缓)和动脉压(低血压)的影响稍弱一些,但最重要的是,它比同等镇痛剂量的吗啡要短得多。其他临床可识别的副作用,特别是患者感觉到的副作用,呕吐和行为模式的改变很小;服用S后的镇静作用明显小于服用m后的镇静作用。两种药物服用后镇静作用是相同的,通常是相同的。最后,舒芬太尼的欣快效果似乎比吗啡轻微。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Sulfentanil and morphine by intramuscular injection. Side effects compared in conscious man (author's transl)].

For the purposes of this study, sulfentanil is administered to conscious men in increasing doses (0,00015, 0,0003, 0,0006 mg/kg) by intra-muscular injection, and the results are compared with those obtained in the same condition by administration of morphine (0,100, 0,150, 0,200 mg/kg). The administration of both drugs provokes the same side-effects. The failure of the breathing rate is as fast as observed following the administration of morphine in equi-analgesic doses. As in the case of analgesia, the time taken for the falling off of the breathing rate to occur, and its duration are shorter with sulfentanil, than with morphine. In any case their persistence is too great for one, to be able to consider sulfentanil as a drug of very short-term effect. The effects of sulfentanil on the cardiac rhythm (bradycardia) and on arterial pressure (low blood pressure) are slightly less intense, but above all, much shorter than that of a equi-analgesic dose of morphine. The other side-effects which are clinically discernable, particularly those felt by the patient, vomiting and changes in behaviour patterns are minimal; certainly lesser after administration of S than after tha of M. The sedative value are the same and often identical after administration of both drugs. Finally, the euphoric effect of sulfentanil appears to be slighter than that of morphine.

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