新生儿药物不良反应的相关因素。

Pediatric pharmacology (New York, N.Y.) Pub Date : 1983-01-01

J V Aranda

{"title":"新生儿药物不良反应的相关因素。","authors":"J V Aranda","doi":"","DOIUrl":null,"url":null,"abstract":"Risk factors associated with the occurrence of adverse drug reactions were evaluated in 1,200 neonates in an intensive care setting. Three-hundred-and-twenty-six neonates (27.1%) developed at least one ADR, 153 of whom had moderate to severe (fatal or life threatening) ADR. Severe prematurity (less than 28 weeks) gestation and diseases of prematurity (eg, RDS, apnea, and necrotizing enterocolitis) as well as the use of mechanical ventilation and parenteral nutrition were associated with highly significant increase in ADR occurrence. Impairment of liver and renal function both predisposed neonates to develop ADR.","PeriodicalId":77932,"journal":{"name":"Pediatric pharmacology (New York, N.Y.)","volume":"3 3-4","pages":"245-9"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Factors associated with adverse drug reactions in the newborn.\",\"authors\":\"J V Aranda\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Risk factors associated with the occurrence of adverse drug reactions were evaluated in 1,200 neonates in an intensive care setting. Three-hundred-and-twenty-six neonates (27.1%) developed at least one ADR, 153 of whom had moderate to severe (fatal or life threatening) ADR. Severe prematurity (less than 28 weeks) gestation and diseases of prematurity (eg, RDS, apnea, and necrotizing enterocolitis) as well as the use of mechanical ventilation and parenteral nutrition were associated with highly significant increase in ADR occurrence. Impairment of liver and renal function both predisposed neonates to develop ADR.\",\"PeriodicalId\":77932,\"journal\":{\"name\":\"Pediatric pharmacology (New York, N.Y.)\",\"volume\":\"3 3-4\",\"pages\":\"245-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric pharmacology (New York, N.Y.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric pharmacology (New York, N.Y.)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

与药物不良反应发生相关的危险因素对1200名重症监护新生儿进行了评估。326名新生儿(27.1%)出现至少一种ADR，其中153名为中度至重度(致命或危及生命)ADR。严重早产(小于28周)和早产儿疾病(如RDS、呼吸暂停和坏死性小肠结肠炎)以及机械通气和肠外营养的使用与不良反应发生率的显著增加相关。肝肾功能损害都易使新生儿发生不良反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Factors associated with adverse drug reactions in the newborn.

Risk factors associated with the occurrence of adverse drug reactions were evaluated in 1,200 neonates in an intensive care setting. Three-hundred-and-twenty-six neonates (27.1%) developed at least one ADR, 153 of whom had moderate to severe (fatal or life threatening) ADR. Severe prematurity (less than 28 weeks) gestation and diseases of prematurity (eg, RDS, apnea, and necrotizing enterocolitis) as well as the use of mechanical ventilation and parenteral nutrition were associated with highly significant increase in ADR occurrence. Impairment of liver and renal function both predisposed neonates to develop ADR.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pediatric pharmacology (New York, N.Y.)

自引率

0.00%

发文量