[人粒细胞膜唾液酸在刺激NADPH、H+氧化酶活性中的作用]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-01

G Sarfati, D Raichvarg, C Pasquier, B Amor, J Agneray

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引用次数: 0

摘要

用神经氨酸酶“x型”处理人多形核细胞，可去除约15%的细胞唾液酸，而不改变粒细胞在经活化酶酶体刺激前后的NADPH氧化酶活性。温和的高碘酸盐处理只氧化唾液酸的多羟基链，形成醛基。这种处理增加了细胞NADPH氧化酶的活性，并在很大程度上阻止了调理酶对多形核细胞的刺激。

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[Role of membrane sialic acid of human granulocytes in the stimulation of NADPH,H+ oxidase activity].

The treatment of human polymorphonuclear cells by neuraminidase "type-X" removes about 15% of cell sialic acid without modifications of NADPH oxidase activity of granulocytes before and after stimulation by opsonized zymosan. A mild periodate treatment oxidizes only the poly-hydroxilic chain of sialic acid with formation of aldehyde groups. This treatment increases cellular NADPH oxidase activity and also largely prevents the stimulation of polymorphonuclear cells by opsonized zymosan.

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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