[用分光光度法测定3种抗镰状细胞物质与氧压的关系]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-01

C J Feo, R M Johnson, M Nossal

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引用次数: 0

摘要

在连续的氧张力变化过程中，红细胞的变形能力精确测量。该仪器的自动化使所提出的抗镰状结化合物的评价容易实现。目前公认的三种作用模式的代表性药物已被选择:增加氧亲和力的药物(氰酸钾);抑制血红蛋白聚合的(丁脲);membrane-active化合物。阴离子型吩噻嗪(甲氮酸)对变形性有显著影响。

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[Effects of 3 varieties of antisickling substances measured by ektacytometry as a function of oxygen pressure].

The ektacytometer measures with precision the deformability of erythrocytes during a continuous change in oxygen tension. Automation of the instrument renders easily feasible the evaluation of proposed antisickling compounds. Drugs representative of the three modes of action presently recognized have been selected: those which increase oxygen affinity (potassium cyanate); those which inhibit hemoglobin polymerization (butylurea); membrane-active compounds. An anionic phenothiazine (metiazinic acid) had an interesting activity on deformability.

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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