选择方法评价药物对黏液粘弹性和黏毛清除率的影响。

Biorheology. Supplement : the official journal of the International Society of Biorheology Pub Date : 1984-01-01 DOI:10.3233/bir-1984-23s123

A E Bell, S L James, C Marriott

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引用次数: 4

摘要

为了合理地测试黏液溶粘剂和黏液增粘剂的功效，必须确定它们对黏液粘弹性、纤毛跳动频率(c.b.f)和总黏毛运输率(t.t.r)的影响。方法描述，允许测量粘弹性模量的小(10微升)的粘液量，而c.b.f.和t.t.r.是确定使用蛙腭模型。

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Selected methods for the evaluation of the effects of drugs on mucus viscoelasticity and mucociliary clearance.

In order to rationally test the efficacy of mucolytic and mucospissic compounds, their effects upon mucus viscoelasticity, ciliary beat frequency (c.b.f.) and total mucociliary transport rate (t.t.r.) must all be determined. Methods are described which allow the measurement of the viscoelastic modulii of small (10 microL) quantities of mucus, while c.b.f. and t.t.r. are determined using the frog palate model.

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Biorheology. Supplement : the official journal of the International Society of Biorheology

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