水参与视网膜电活动的机制。

Physiological chemistry and physics Pub Date : 1982-01-01
E Chirieri-Kovacs, V Vasilescu
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引用次数: 0

摘要

视网膜是一个易兴奋的系统,大约含有90%的水。我们发现氘化选择性地改变视网膜生物电位的振幅和潜伏期,特别是ON和OFF反应,我们用它来探测水在这些过程中的作用。同时进行了视网膜氘化动力学的研究。这表明至少存在两个视网膜水室。数据表明,还有第三个隔室,其运动“自由度”较低,只有在前两个隔室的D2O饱和后,H2O-D2O交换才变得重要。D2O的电生理效应与动力学数据的相关性表明,ON响应与第一个水室有关,OFF响应与第三个水室有关。结果指出了独立的on和OFF反应机制,很可能,他们不同的形态起源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Water involvement in the mechanisms of retina electrical activity.

Retina is an excitable system containing approximately 90% water. As we found that deuteration selectively changes amplitudes and latencies of retina biopotentials, specifically the ON and OFF responses, we used it to probe the role of water in those processes. A study of the retina deuteration kinetics was simultaneously performed. This revealed the existence of at least two retinal water compartments. The data suggested a third compartment also, with a lower motional "degree of freedom," existing where H2O-D2O exchange becomes important only after saturation by D2O of the first two compartments. Correlation of the electrophysiological effects of D2O with the kinetic data suggests that the ON response is related to the first water compartment and the OFF response to the third. The results point to independence on the ON and OFF response mechanisms and, very probably, to their different morphological origins.

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