[在分泌催乳素的人垂体腺瘤中存在甲状腺素高亲和力结合位点]。

Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie Pub Date : 1983-01-10

M Le Dafniet, A M Brandi, D Bression, J Racadot, F Peillon

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引用次数: 0

摘要

促甲状腺激素释放激素(TRH)在人催乳素分泌腺瘤的细胞膜上具有特异性的高亲和力结合位点，尽管体内催乳素对TRH缺乏反应。鉴定了一个结合位点。4个腺瘤的Kd平均值为64.8 +/- 12.5 nM。最大结合位点数量因腺瘤而异(从80到450 fmol /mg膜蛋白)。

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[Presence of high-affinity binding sites for thyroliberin in human pituitary adenomas secreting prolactin].

Specific high affinity binding sites for thyrotropin-releasing hormone (TRH) were demonstrated on cellular membranes from human prolactin-secreting adenomas in spite of the lack of in vivo prolactin response to TRH. One binding site was characterized. The mean value for the Kd from four adenomas was 64.8 +/- 12.5 nM. The maximal number of binding sites varied from one adenoma to another (from 80 to 450 fmoles/mg membrane proteins).

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Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie

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