{"title":"二氧化硅和粉煤灰粉尘吸入对肺泡巨噬细胞效应细胞功能的影响。","authors":"C A Burns, A Zarkower","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Inhalation of silica was found to cause significant enhancement of alveolar macrophage antibody-dependent cell-mediated cytotoxicity (ADCC) after 14, 42, and 70 days of exposure, while similar treatment using fly ash resulted in significant suppression of ADCC after 42 days of exposure. Both silica and fly ash inhalation depressed the ability of alveolar macrophages from BCG-primed and BCG-rechallenged animals to mediate tumor cell lysis. Fly ash exposure also significantly suppressed the ability of BCG-activated macrophages to lyse target cells by the ADCC mechanism.</p>","PeriodicalId":17481,"journal":{"name":"Journal of the Reticuloendothelial Society","volume":"32 6","pages":"449-59"},"PeriodicalIF":0.0000,"publicationDate":"1982-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of silica and fly ash dust inhalation on alveolar macrophage effector cell function.\",\"authors\":\"C A Burns, A Zarkower\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Inhalation of silica was found to cause significant enhancement of alveolar macrophage antibody-dependent cell-mediated cytotoxicity (ADCC) after 14, 42, and 70 days of exposure, while similar treatment using fly ash resulted in significant suppression of ADCC after 42 days of exposure. Both silica and fly ash inhalation depressed the ability of alveolar macrophages from BCG-primed and BCG-rechallenged animals to mediate tumor cell lysis. Fly ash exposure also significantly suppressed the ability of BCG-activated macrophages to lyse target cells by the ADCC mechanism.</p>\",\"PeriodicalId\":17481,\"journal\":{\"name\":\"Journal of the Reticuloendothelial Society\",\"volume\":\"32 6\",\"pages\":\"449-59\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Reticuloendothelial Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Reticuloendothelial Society","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effects of silica and fly ash dust inhalation on alveolar macrophage effector cell function.
Inhalation of silica was found to cause significant enhancement of alveolar macrophage antibody-dependent cell-mediated cytotoxicity (ADCC) after 14, 42, and 70 days of exposure, while similar treatment using fly ash resulted in significant suppression of ADCC after 42 days of exposure. Both silica and fly ash inhalation depressed the ability of alveolar macrophages from BCG-primed and BCG-rechallenged animals to mediate tumor cell lysis. Fly ash exposure also significantly suppressed the ability of BCG-activated macrophages to lyse target cells by the ADCC mechanism.
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