细胞静息电位和动作电位:基于联想-诱导假说的解释。

Physiological chemistry and physics Pub Date : 1982-01-01
G N Ling
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引用次数: 0

摘要

霍奇金、赫胥黎和卡茨的静息电位和动作电位理论是建立在膜理论的基础上的,该理论认为细胞中的钾离子和水以自由状态存在。本文就这些细胞电位理论及实验结果进行综述。Ling的关联诱导(association-induction, AI)假说也进行了回顾,该假说认为,所有的K+都是选择性地、单一地在阴离子蛋白位点上被吸收,而细胞水是在“基质蛋白”的延伸链上被多层吸收的。在AI模型的开发中,提出了细胞渗透和电势的分子机制,根据电势是表面吸附现象。因此,它们类似于Baur提出的膜电位,而不是Ostwald和Bernstein提出的膜电位。在本综述中表明,人工智能版本的表面吸附模型可以解释支持Hodgkin, Huxley, Katz方法的证据,也可以解释反对它的证据,包括最近对肌肉中K+吸收状态的广泛确认。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The cellular resting and action potentials: interpretation based on the association-induction hypothesis.

The Hodgkin, Huxley, and Katz theories of resting and action potentials are based on the membrane theory, which holds that cell K+ and water exist in the free state. Reviewed here are these theories of cellular potential along with the results of experimental testings. Reviewed also is Ling's association-induction (AI) hypothesis, which holds that all K+ is absorbed selectively and singly on anionic protein sites and that cell water is absorbed in multilayers on extended chains of "matrix proteins." In the development of the AI model, molecular mechanisms of cell permeation and electric potentials were presented according to which the potentials are surface-adsorption phenomena. Thus they resemble those suggested by Baur rather than the membrane potentials proposed by Ostwald and Bernstein. In the present review it is shown that the AI version of the surface adsorption model can account for evidence supporting the Hodgkin, Huxley, Katz approach as well as evidence against it-including extensive recent confirmation of the absorbed state of K+ in muscle.

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