人结肠腺癌中蛋白激酶活性和同工酶分布的改变。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-07-01

F Raul, J F Launay, M Galluser, M Doffoël, J Marescaux, J F Grenier

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引用次数: 0

摘要

蛋白激酶活性和组蛋白激酶同工酶分布已确定在可溶性提取物的人结肠腺癌和相邻的正常粘膜比较。结果显示内源性蛋白激酶活性增强，肿瘤组织中存在额外的组蛋白激酶同工酶(PKI)。与同工酶相比，PKI活性表现出一种特殊的行为。可溶性提取物透析后，PKII在癌和正常粘膜中均存在。这表明，参与PKI活性的细胞内调节过程的改变可能与人类结肠癌细胞增殖状态的维持有关。

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Modified protein kinase activity and isozyme distribution in adenocarcinoma of the human colon.

Protein kinase activity and histone kinase isozyme distribution have been determined in soluble extracts of adenocarcinoma of the human colon and compared to adjacent normal mucosa. The results show an enhancement in endogenous protein kinase activity and the presence of an additional isozyme (PKI) for histone kinase activity in the tumour tissue. PKI activity exhibited a peculiar behaviour in comparison to the isozyme. PKII present in both carcinoma and normal mucosa after dialysis of the soluble extracts. It is suggested that alteration of intracellular regulatory processes involved in PKI activity might be related to the maintenance of the proliferate state in human colon carcinoma.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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