J Boyer, G Sohaleh, Y Frobert, J F Cordier, R Touraine
{"title":"[结节病患者血液和支气管肺泡灌洗(BAL)中T淋巴细胞亚群的单克隆抗体分型]。","authors":"J Boyer, G Sohaleh, Y Frobert, J F Cordier, R Touraine","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Cell typing of sub-populations of lymphocytes is facilitated by using monoclonal antibodies (OKT); with this technique we determined the relative proportions of \"helper\" T-lymphocytes (OKT4) and \"Suppressor\" T-lymphocytes (OKT8) in the blood and the LBA of 13 patients suffering from pulmonary sarcoidosis. In the control subjects the OKT4/OKT8 ratio was 1.9 +/- 0.3 in the blood (38 subjects) and of 2 +/- 0.2 in the LBA (6 subjects). Six patients suffering from inactive sarcoidosis (stabilised) had an OKT4/OKT8 ratio on average of 1.2 +/- 0.39 in the blood and of 1.86 +/- 0.46 in the LBA. By contrast in 7 patients suffering from \"active\" sarcoidosis, on average the ratio was 1.88 +/- 1.20 in the blood but 5.13 +/- 3.51 in the LBA; this ratio was notably raised in the LBA in 5 cases and was due as much to an increase in the T-\"Helper\" (OKT4) percentage as to a fall in the T-\"Suppressor\" (OKT8). It is probable that the T-\"Helper\" lymphocytes found in great numbers in the lung in active sarcoidosis cases participate in the formation of sarcoid granulomas and attract phagocytic mononuclear cells. This phenomenon seems to correspond to a local immune disturbance without producing a similar result in the peripheral blood of the patients.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 6","pages":"889-98"},"PeriodicalIF":0.0000,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Monoclonal antibody typing of sub-populations of T lymphocytes in the blood and broncho-alveolar lavage (BAL) in sarcoidosis].\",\"authors\":\"J Boyer, G Sohaleh, Y Frobert, J F Cordier, R Touraine\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cell typing of sub-populations of lymphocytes is facilitated by using monoclonal antibodies (OKT); with this technique we determined the relative proportions of \\\"helper\\\" T-lymphocytes (OKT4) and \\\"Suppressor\\\" T-lymphocytes (OKT8) in the blood and the LBA of 13 patients suffering from pulmonary sarcoidosis. In the control subjects the OKT4/OKT8 ratio was 1.9 +/- 0.3 in the blood (38 subjects) and of 2 +/- 0.2 in the LBA (6 subjects). Six patients suffering from inactive sarcoidosis (stabilised) had an OKT4/OKT8 ratio on average of 1.2 +/- 0.39 in the blood and of 1.86 +/- 0.46 in the LBA. By contrast in 7 patients suffering from \\\"active\\\" sarcoidosis, on average the ratio was 1.88 +/- 1.20 in the blood but 5.13 +/- 3.51 in the LBA; this ratio was notably raised in the LBA in 5 cases and was due as much to an increase in the T-\\\"Helper\\\" (OKT4) percentage as to a fall in the T-\\\"Suppressor\\\" (OKT8). It is probable that the T-\\\"Helper\\\" lymphocytes found in great numbers in the lung in active sarcoidosis cases participate in the formation of sarcoid granulomas and attract phagocytic mononuclear cells. This phenomenon seems to correspond to a local immune disturbance without producing a similar result in the peripheral blood of the patients.</p>\",\"PeriodicalId\":76480,\"journal\":{\"name\":\"Revue francaise des maladies respiratoires\",\"volume\":\"11 6\",\"pages\":\"889-98\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1983-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue francaise des maladies respiratoires\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue francaise des maladies respiratoires","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Monoclonal antibody typing of sub-populations of T lymphocytes in the blood and broncho-alveolar lavage (BAL) in sarcoidosis].
Cell typing of sub-populations of lymphocytes is facilitated by using monoclonal antibodies (OKT); with this technique we determined the relative proportions of "helper" T-lymphocytes (OKT4) and "Suppressor" T-lymphocytes (OKT8) in the blood and the LBA of 13 patients suffering from pulmonary sarcoidosis. In the control subjects the OKT4/OKT8 ratio was 1.9 +/- 0.3 in the blood (38 subjects) and of 2 +/- 0.2 in the LBA (6 subjects). Six patients suffering from inactive sarcoidosis (stabilised) had an OKT4/OKT8 ratio on average of 1.2 +/- 0.39 in the blood and of 1.86 +/- 0.46 in the LBA. By contrast in 7 patients suffering from "active" sarcoidosis, on average the ratio was 1.88 +/- 1.20 in the blood but 5.13 +/- 3.51 in the LBA; this ratio was notably raised in the LBA in 5 cases and was due as much to an increase in the T-"Helper" (OKT4) percentage as to a fall in the T-"Suppressor" (OKT8). It is probable that the T-"Helper" lymphocytes found in great numbers in the lung in active sarcoidosis cases participate in the formation of sarcoid granulomas and attract phagocytic mononuclear cells. This phenomenon seems to correspond to a local immune disturbance without producing a similar result in the peripheral blood of the patients.