唾液化学在Sjögren综合征中的临床应用。

R N Stuchell, I D Mandel, H Baurmash
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引用次数: 71

摘要

对一组伴有4级淋巴细胞浸润的Sjögren综合征(SS)患者和正常对照组的受刺激腮腺分泌物进行了唾液化学检测。检测的参数包括流速、钠、钾、氯化物、尿素、钙、磷酸盐、总蛋白、IgA、IgG的浓度。白蛋白,淀粉酶和乳铁蛋白。虽然所有SS患者在没有刺激的情况下几乎没有腮腺分泌,但在味觉刺激下,与对照组相比,40%的SS患者腮腺流量相对正常。与对照组相比,无论流量如何,SS患者的钠、氯、IgA、IgG和乳铁蛋白浓度均显著升高(p < 0.01),白蛋白浓度显著升高(p < 0.05)。与对照组相比,SS患者血清磷酸水平显著降低(p < 0.01)。SS中升高的IgA几乎都是11S,而腮腺炎中7S是主要的贡献者。考虑到SS患者唾液流率的变化,对选定的唾液成分进行化学定量分析可以对该病的鉴别诊断和长期监测患者提供有价值的帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical utilization of sialochemistry in Sjögren's syndrome.

Sialochemistry was performed on the stimulated parotid secretion of a group of patients with Sjögren's syndrome (SS) having a Grade 4 lymphocytic infiltrate of their minor labial salivary glands and a normal control group. Parameters examined included flow rate, and concentration of sodium, potassium, chloride, urea, calcium, phosphate, total protein, IgA, IgG. albumin, amylase and lactoferrin. Although all SS patients had virtually no parotid secretion in the absence of stimulation, with a gustatory stimulation, 40% of the patients with SS had a relatively normal parotid flow rate, when compared with the control group. The SS patients, regardless of flow rate, exhibited a highly significant (p less than 0.01) elevation in the concentration of sodium, chloride, IgA, IgG, and lactoferrin and a significant (p less than 0.05) increase in albumin concentration, when compared with the control group. The phosphate level was significantly lower (p less than 0.01) in SS patients than in the control group. The elevated IgA in SS was almost all 11S, in contrast to parotitis where 7S was a major contributor. In view of the variation in flow rate in SS patients chemical quantitation of selected salivary components can be a valuable aid in the differential diagnosis of this disease and in monitoring patients over time.

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