{"title":"干扰素:化学性质。","authors":"K H Fantes","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>HuIFN-alpha has been found to consist of a family of 8-10 components. Their amino acid (165 and 166 residues) and nucleotide sequences are similar and also reveal some relationship to that of HuIFN-beta and even to those of murine alpha- and beta-interferons. It is thus likely that all mammalian interferons have originated from a common ancestral gene. Human beta- and some alpha-interferons have been obtained by genetic engineering in E.coli. All interferons seem to contain a relatively high proportion of hydrophobic amino acids and some of the components are glycosylated. The N-terminal residue of all HuIFN-alpha members is probably cysteine, that of the major HuIFN-beta peptide methionine and that of MuIFN-alpha and-beta probably alanine and isoleucine. Very little is known about the chemistry of any of the gamma-interferon species.</p>","PeriodicalId":76584,"journal":{"name":"Texas reports on biology and medicine","volume":"41 ","pages":"240-9"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interferons: chemical properties.\",\"authors\":\"K H Fantes\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>HuIFN-alpha has been found to consist of a family of 8-10 components. Their amino acid (165 and 166 residues) and nucleotide sequences are similar and also reveal some relationship to that of HuIFN-beta and even to those of murine alpha- and beta-interferons. It is thus likely that all mammalian interferons have originated from a common ancestral gene. Human beta- and some alpha-interferons have been obtained by genetic engineering in E.coli. All interferons seem to contain a relatively high proportion of hydrophobic amino acids and some of the components are glycosylated. The N-terminal residue of all HuIFN-alpha members is probably cysteine, that of the major HuIFN-beta peptide methionine and that of MuIFN-alpha and-beta probably alanine and isoleucine. Very little is known about the chemistry of any of the gamma-interferon species.</p>\",\"PeriodicalId\":76584,\"journal\":{\"name\":\"Texas reports on biology and medicine\",\"volume\":\"41 \",\"pages\":\"240-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Texas reports on biology and medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Texas reports on biology and medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HuIFN-alpha has been found to consist of a family of 8-10 components. Their amino acid (165 and 166 residues) and nucleotide sequences are similar and also reveal some relationship to that of HuIFN-beta and even to those of murine alpha- and beta-interferons. It is thus likely that all mammalian interferons have originated from a common ancestral gene. Human beta- and some alpha-interferons have been obtained by genetic engineering in E.coli. All interferons seem to contain a relatively high proportion of hydrophobic amino acids and some of the components are glycosylated. The N-terminal residue of all HuIFN-alpha members is probably cysteine, that of the major HuIFN-beta peptide methionine and that of MuIFN-alpha and-beta probably alanine and isoleucine. Very little is known about the chemistry of any of the gamma-interferon species.
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