黄曲霉毒素B1诱导大鼠肝门静脉转移致肝癌的增强作用。

Biomedicine / [publiee pour l'A.A.I.C.I.G.] Pub Date : 1981-10-01

D Franco, J Morin, A M Szekely, H Bismuth

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引用次数: 0

摘要

关于门静脉吻合对肝癌发生的影响，已有相互矛盾的结果报道。本研究的目的是研究门脉分流对强效化学致癌物黄曲霉毒素B1 (AFB1)诱导大鼠肝癌的影响。与假手术对照组相比，分流组的大鼠肝脏肿瘤出现得更早，而且明显更大。注射AFB1后，门脉分流也引起大鼠脾萎缩，马尔比氏小体几乎完全消失，提示免疫深度抑制。这可能是AFB1喂养大鼠门静脉吻合术增强肝癌的原因。因此，门静脉转移对肝癌的影响似乎是多因素的。

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Enhancement of Aflatoxin B1 induced liver carcinogenesis by portal diversion in the rat.

Conflicting results have been reported on the influence of portacaval anastomosis on liver carcinogenesis. The purpose of this investigation was to study the effect of portal diversion on liver carcinogenesis induced in the rat by a potent chemical liver carcinogen, Aflatoxin B1 (AFB1). Liver tumors appeared earlier and were significantly bigger in rats with shunts than in sham-operated controls. Portal diversion also induced in rats fed AFB1 a splenic atrophy with nearly complete disappearance of Malpighian corpuscles suggesting a profound immunodepression. This might be responsible for the enhancement of liver cancer by portacaval anastomosis in the rats fed AFB1. Thus, the influence of portal diversion on liver cancers appears to be multifactorial.

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Biomedicine / [publiee pour l'A.A.I.C.I.G.]

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