{"title":"被隔离的动物可能是恐惧和焦虑的模型吗?","authors":"Silvio Garattini, Luigi Valzelli","doi":"10.1016/0364-7722(81)90065-5","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. Isolated animals develop a complex symptopathology which can be characterized both behaviorally and neurochemically.</p></span></li><li><span>2.</span><span><p>2. The main behavioral features include: compulsive aggression, impairment of learning, exploration and sexual behavior, while the main neurochemical features include a decrease of brain tryptophan content and of brain serotonin turnover and an increased brain dopamine turnover.</p></span></li><li><span>3.</span><span><p>3. Isolated aggressive mice are differently sensitive than grouped animals and respond differently to several psychotropic drugs, tricyclic antidepressants, betablockers and benzodiazepines.</p></span></li><li><span>4.</span><span><p>4. The results obtained will be discussed in the frame of the possibility of utilizing these animals models to study drugs active on anxiety and phobia.</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90065-5","citationCount":"18","resultStr":"{\"title\":\"Is the isolated animal a possible model for phobia and anxiety?\",\"authors\":\"Silvio Garattini, Luigi Valzelli\",\"doi\":\"10.1016/0364-7722(81)90065-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p></p><ul><li><span>1.</span><span><p>1. Isolated animals develop a complex symptopathology which can be characterized both behaviorally and neurochemically.</p></span></li><li><span>2.</span><span><p>2. The main behavioral features include: compulsive aggression, impairment of learning, exploration and sexual behavior, while the main neurochemical features include a decrease of brain tryptophan content and of brain serotonin turnover and an increased brain dopamine turnover.</p></span></li><li><span>3.</span><span><p>3. Isolated aggressive mice are differently sensitive than grouped animals and respond differently to several psychotropic drugs, tricyclic antidepressants, betablockers and benzodiazepines.</p></span></li><li><span>4.</span><span><p>4. The results obtained will be discussed in the frame of the possibility of utilizing these animals models to study drugs active on anxiety and phobia.</p></span></li></ul></div>\",\"PeriodicalId\":20801,\"journal\":{\"name\":\"Progress in neuro-psychopharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0364-7722(81)90065-5\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in neuro-psychopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0364772281900655\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281900655","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Is the isolated animal a possible model for phobia and anxiety?
1.
1. Isolated animals develop a complex symptopathology which can be characterized both behaviorally and neurochemically.
2.
2. The main behavioral features include: compulsive aggression, impairment of learning, exploration and sexual behavior, while the main neurochemical features include a decrease of brain tryptophan content and of brain serotonin turnover and an increased brain dopamine turnover.
3.
3. Isolated aggressive mice are differently sensitive than grouped animals and respond differently to several psychotropic drugs, tricyclic antidepressants, betablockers and benzodiazepines.
4.
4. The results obtained will be discussed in the frame of the possibility of utilizing these animals models to study drugs active on anxiety and phobia.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
