乙肝病毒DNA在人肝癌组织中表达的直接证据。

Gan Pub Date : 1984-09-01

K Yaginuma, H Kobayashi, E Yoshida, M Kobayashi, K Koike

{"title":"乙肝病毒DNA在人肝癌组织中表达的直接证据。","authors":"K Yaginuma, H Kobayashi, E Yoshida, M Kobayashi, K Koike","doi":"","DOIUrl":null,"url":null,"abstract":"The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.","PeriodicalId":12660,"journal":{"name":"Gan","volume":"75 9","pages":"743-6"},"PeriodicalIF":0.0000,"publicationDate":"1984-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue.\",\"authors\":\"K Yaginuma, H Kobayashi, E Yoshida, M Kobayashi, K Koike\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.\",\"PeriodicalId\":12660,\"journal\":{\"name\":\"Gan\",\"volume\":\"75 9\",\"pages\":\"743-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gan","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

研究了一名11岁男孩肝癌组织#1707中乙型肝炎病毒DNA的细胞内结构和表达。结果发现，大部分HBV基因组存在于#1707 DNA中。印迹杂交也证实了病毒特异性的21S mRNA。这是人类肝癌组织中整合病毒基因组表达的第一个直接证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Direct evidence for the expression of integrated hepatitis B virus DNA in human hepatoma tissue.

The intracellular structure and expression of integrated hepatitis B virus (HBV) DNA in the hepatoma tissue #1707 obtained from an 11-year-old boy were studied. It was found that most of the HBV genome was present in the #1707 DNA. Virus-specific 21S mRNA was also demonstrated by blot hybridization. This is the first direct evidence for the expression of the integrated viral genome in human hepatoma tissue.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Gan

自引率

0.00%

发文量