{"title":"磷脂的物理研究2。含反式双键的2,3-二酰基-dl-磷脂酰乙醇胺和磷脂酰胆碱的单层合成研究","authors":"D. Chapman, N.F. Owens, D.A. Walker","doi":"10.1016/0926-6585(66)90286-X","DOIUrl":null,"url":null,"abstract":"<div><p>In order to study the influence of the <em>trans</em> double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic <span>dl</span>-phosphatidylethanolamines and <span>dl</span>-phosphatidylcholines containing fatty acid residues with <em>rans</em> double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing <em>cis</em> groupings in the 2-position of the phospholipid, and it is shown that replacement of <em>cis</em> by a <em>trans</em> double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the <em>trans</em> phospholipids has also been measured and is found to be less favourable than with the isomeric <em>cis</em> phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.</p></div>","PeriodicalId":100158,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis","volume":"120 1","pages":"Pages 148-155"},"PeriodicalIF":0.0000,"publicationDate":"1966-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6585(66)90286-X","citationCount":"114","resultStr":"{\"title\":\"Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds\",\"authors\":\"D. Chapman, N.F. Owens, D.A. Walker\",\"doi\":\"10.1016/0926-6585(66)90286-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In order to study the influence of the <em>trans</em> double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic <span>dl</span>-phosphatidylethanolamines and <span>dl</span>-phosphatidylcholines containing fatty acid residues with <em>rans</em> double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing <em>cis</em> groupings in the 2-position of the phospholipid, and it is shown that replacement of <em>cis</em> by a <em>trans</em> double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the <em>trans</em> phospholipids has also been measured and is found to be less favourable than with the isomeric <em>cis</em> phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.</p></div>\",\"PeriodicalId\":100158,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis\",\"volume\":\"120 1\",\"pages\":\"Pages 148-155\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1966-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6585(66)90286-X\",\"citationCount\":\"114\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092665856690286X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092665856690286X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds
In order to study the influence of the trans double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic dl-phosphatidylethanolamines and dl-phosphatidylcholines containing fatty acid residues with rans double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing cis groupings in the 2-position of the phospholipid, and it is shown that replacement of cis by a trans double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the trans phospholipids has also been measured and is found to be less favourable than with the isomeric cis phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.