磷脂的物理研究2。含反式双键的2,3-二酰基-dl-磷脂酰乙醇胺和磷脂酰胆碱的单层合成研究

D. Chapman, N.F. Owens, D.A. Walker
{"title":"磷脂的物理研究2。含反式双键的2,3-二酰基-dl-磷脂酰乙醇胺和磷脂酰胆碱的单层合成研究","authors":"D. Chapman,&nbsp;N.F. Owens,&nbsp;D.A. Walker","doi":"10.1016/0926-6585(66)90286-X","DOIUrl":null,"url":null,"abstract":"<div><p>In order to study the influence of the <em>trans</em> double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic <span>dl</span>-phosphatidylethanolamines and <span>dl</span>-phosphatidylcholines containing fatty acid residues with <em>rans</em> double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing <em>cis</em> groupings in the 2-position of the phospholipid, and it is shown that replacement of <em>cis</em> by a <em>trans</em> double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the <em>trans</em> phospholipids has also been measured and is found to be less favourable than with the isomeric <em>cis</em> phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.</p></div>","PeriodicalId":100158,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis","volume":"120 1","pages":"Pages 148-155"},"PeriodicalIF":0.0000,"publicationDate":"1966-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6585(66)90286-X","citationCount":"114","resultStr":"{\"title\":\"Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds\",\"authors\":\"D. Chapman,&nbsp;N.F. Owens,&nbsp;D.A. Walker\",\"doi\":\"10.1016/0926-6585(66)90286-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In order to study the influence of the <em>trans</em> double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic <span>dl</span>-phosphatidylethanolamines and <span>dl</span>-phosphatidylcholines containing fatty acid residues with <em>rans</em> double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing <em>cis</em> groupings in the 2-position of the phospholipid, and it is shown that replacement of <em>cis</em> by a <em>trans</em> double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the <em>trans</em> phospholipids has also been measured and is found to be less favourable than with the isomeric <em>cis</em> phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.</p></div>\",\"PeriodicalId\":100158,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis\",\"volume\":\"120 1\",\"pages\":\"Pages 148-155\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1966-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6585(66)90286-X\",\"citationCount\":\"114\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/092665856690286X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Biophysics including Photosynthesis","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/092665856690286X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 114

摘要

为了研究反式双键对磷脂表面性质的影响,测定了含反式双键脂肪酸残基的合成dl-磷脂酰乙醇胺和dl-磷脂酰胆碱单分子膜的压力面积曲线。所得结果与含有2位顺式基团的同分异构体磷脂的结果进行了比较,结果表明,用反式双键取代顺式基团使单分子膜在性质上明显更浓缩。在不同温度下观察到一些单分子薄膜的相变。还测量了胆固醇与反式磷脂的关系,发现与同分异构体顺式磷脂相比,胆固醇与反式磷脂的关系更不利。讨论了这种行为对生物膜性能的可能影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical studies of phospholipids II. Monolayer studies of some synthetic 2,3-diacyl-dl-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds

In order to study the influence of the trans double bond on the surface properties of phospholipids, pressure-area curves of monomolecular films of synthetic dl-phosphatidylethanolamines and dl-phosphatidylcholines containing fatty acid residues with rans double bonds have been measured. The results obtained are compared with those obtained with isomeric phospholipids containing cis groupings in the 2-position of the phospholipid, and it is shown that replacement of cis by a trans double bond causes the monomolecular films to be apprechiably more condensed in character. Phase transitions are observed at different temperatures with some of the monomolecular films. The association of cholesterol with the trans phospholipids has also been measured and is found to be less favourable than with the isomeric cis phospholipids. Possible implications of this behaviour to biological membrane properties are discussed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信