Navigating recent advances in monoelemental materials (Xenes)-fundamental to biomedical applications

The emergence of new two-dimensional materials (2DMs), especially the monoelemental materials (Xenes), in various fields of technology for their uses has shown potential nature, additionally, to fundamental science, addressing the new discoveries. The 2DMs Xenes (e.g., Group-IIIA (Borophene (2D-B), Gallenene (2D-Ga), and Aluminene (2D-Al)) Group-IVA (Silicene (2D-Si), Germanene (2D-Ge), Stanene (2D-Sn), and Graphene (2D-G)), Group-VA (Phosphorous (2D-P), Arsenene (2D-As), Antimonene (2D-Sb), and Bismuthene (2D-Bi)), Group-VIA (Tellurene (2D-Te) and Selenene(2D-Se)) for synthetic exploration are chemically tractable materials as considered capable mediators for biomedical applications due to their outstanding chemical, physical, optical and electronic properties, as well as in more than a number of other new bio-uses. In this timely updated review, we explained in detail the categorization of 2D-Xenes derived from their bulkiness properties. We also summarized the modification in synthetic methods of 2D-Xenes as well as their general properties. Moreover, for different biomedical uses the representative 2D-Xenes nanoplatforms are highlighted. At the end of this review, 2D-Xenes in the biomedicines research progress, perspectives, and challenges are discussed.