{"title":"新生儿山羊肺环和股动脉环对托唑啉的敏感性比较。","authors":"R S Green, C W Leffler","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of tolazoline (1 X 10(-5) M) upon the norepinephrine concentration-response relationship is compared in pulmonary and femoral arterial rings from neonatal goats. As we have reported previously in neonatal lambs, the pulmonary vessels are more sensitive to norepinephrine (pED50 7.23 +/- 0.22 for the pulmonary vs. 6.49 +/- 0.42 for the femoral). However, there is no difference in the response to tolazoline of the two vessel types (pKB for tolazoline 5.77 +/- 0.23 in the pulmonary and 5.79 +/- 0.33 in the femoral).</p>","PeriodicalId":77932,"journal":{"name":"Pediatric pharmacology (New York, N.Y.)","volume":"5 2","pages":"91-6"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A comparison of the sensitivities of neonatal hircine pulmonary and femoral arterial rings to tolazoline.\",\"authors\":\"R S Green, C W Leffler\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of tolazoline (1 X 10(-5) M) upon the norepinephrine concentration-response relationship is compared in pulmonary and femoral arterial rings from neonatal goats. As we have reported previously in neonatal lambs, the pulmonary vessels are more sensitive to norepinephrine (pED50 7.23 +/- 0.22 for the pulmonary vs. 6.49 +/- 0.42 for the femoral). However, there is no difference in the response to tolazoline of the two vessel types (pKB for tolazoline 5.77 +/- 0.23 in the pulmonary and 5.79 +/- 0.33 in the femoral).</p>\",\"PeriodicalId\":77932,\"journal\":{\"name\":\"Pediatric pharmacology (New York, N.Y.)\",\"volume\":\"5 2\",\"pages\":\"91-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric pharmacology (New York, N.Y.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric pharmacology (New York, N.Y.)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A comparison of the sensitivities of neonatal hircine pulmonary and femoral arterial rings to tolazoline.
The effect of tolazoline (1 X 10(-5) M) upon the norepinephrine concentration-response relationship is compared in pulmonary and femoral arterial rings from neonatal goats. As we have reported previously in neonatal lambs, the pulmonary vessels are more sensitive to norepinephrine (pED50 7.23 +/- 0.22 for the pulmonary vs. 6.49 +/- 0.42 for the femoral). However, there is no difference in the response to tolazoline of the two vessel types (pKB for tolazoline 5.77 +/- 0.23 in the pulmonary and 5.79 +/- 0.33 in the femoral).
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