口服免疫后C3H/HeJ小鼠IgA系膜沉积。

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

C Genin, J C Sabatier, F C Berthoux

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引用次数: 0

摘要

为了发展实验性IgA肾病，用铁蛋白对高IgA产生者C3H/HeJ小鼠进行口服强免疫，并与C3H/eB小鼠进行比较。免疫后血清IgA和IgG滴度仅在C3H/HeJ小鼠中显著升高。血清中可检出特异性抗铁蛋白抗体。免疫后大部分C3H/HeJ小鼠系膜均有IgA沉积，且明显高于C3H/eB小鼠。肾脏未检出铁蛋白沉积。这些动物均未出现临床表现。

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IgA mesangial deposits in C3H/HeJ mice after oral immunisation.

In order to develop an experimental IgA nephropathy, C3H/HeJ mice, high producers of IgA, were strongly immunised orally by ferritin and compared to C3H/eB mice. After immunisation, serum IgA and IgG titres increased significantly only in C3H/HeJ mice. Specific antiferritin antibody could be detected in the serum. Mesangial IgA deposits were present in most of C3H/HeJ mice after immunisation and were significantly higher than in C3H/eB mice. No ferritin deposits could be detected in the kidney. No clinical manifestation appeared in these animals.

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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