{"title":"线性二次模型中的时间、剂量和分馏问题。","authors":"W Ulmer","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In many problems of modern radiotherapy such as multifractionation, interstitial and intracavitary therapy with implanats the NSD-formula is hardly applicable. Serious difficulties arise, when this formula is used for an estimation of late responses of tissues, because it mainly appreciates acute effects. On the basis of the linear-quadratic survival model S = exp (-alpha D - beta D2) the TDF-problem is investigated with the help of kinetic principles.</p>","PeriodicalId":21981,"journal":{"name":"Strahlentherapie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1985-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"On the problem of time, dose and fractionation (TDF) in the linear-quadratic model.\",\"authors\":\"W Ulmer\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In many problems of modern radiotherapy such as multifractionation, interstitial and intracavitary therapy with implanats the NSD-formula is hardly applicable. Serious difficulties arise, when this formula is used for an estimation of late responses of tissues, because it mainly appreciates acute effects. On the basis of the linear-quadratic survival model S = exp (-alpha D - beta D2) the TDF-problem is investigated with the help of kinetic principles.</p>\",\"PeriodicalId\":21981,\"journal\":{\"name\":\"Strahlentherapie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Strahlentherapie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Strahlentherapie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在现代放射治疗的许多问题中，如多次分割，间质和腔内植入治疗，nsd公式很难适用。当这个公式用于估计组织的晚期反应时，会出现严重的困难，因为它主要评价急性效应。在线性二次生存模型S = exp (- α D - β D2)的基础上，利用动力学原理研究了tdf问题。
On the problem of time, dose and fractionation (TDF) in the linear-quadratic model.
In many problems of modern radiotherapy such as multifractionation, interstitial and intracavitary therapy with implanats the NSD-formula is hardly applicable. Serious difficulties arise, when this formula is used for an estimation of late responses of tissues, because it mainly appreciates acute effects. On the basis of the linear-quadratic survival model S = exp (-alpha D - beta D2) the TDF-problem is investigated with the help of kinetic principles.
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