高比活性[11C]尿素的优化生产

The International journal of applied radiation and isotopes Pub Date : 1985-09-01 DOI:10.1016/0020-708X(85)90046-8

Ali M. Emran, Thomas E. Boothe, Ronald D. Finn, Manhar M. Vora, Paresh J. Kothari, J. Thomas Wooten

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引用次数: 12

摘要

使用[11C]尿素作为中间体制备“无载体添加”放射性药物需要优化合成参数。在轰击结束(EOB)后16±1分钟内，开发了一种由“无载体添加”的11CN -生产[11C]尿素的方法，放射化学产率为95.0±2.5%。

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Optimized production of high specific activity [11C]urea

Use of [¹¹C]urea as an intermediate for the preparation of “no-carrier-added” radiopharmaceuticals required optimization of synthetic parameters. A procedure has been developed to produce [¹¹C]urea from “no-carrier-added” ¹¹CN⁻ within 16 ± 1 min from end of bombardment (EOB) with a radiochemical yield of 95.0 ± 2.5%.

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The International journal of applied radiation and isotopes

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