d-心得安和卡托普利对大鼠缺血后急性肾功能衰竭的影响。

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

M Ishigami, T Maeda, S Yabuki, N T Stowe

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摘要

观察d-心得安与卡托普利联合治疗大鼠缺血后急性肾功能衰竭的疗效。缺血损伤后24小时，未用药组的肾小球滤过率为54 +/- 11微升/min/100g体重，而d-心得安与卡托普利联合用药组的肾小球滤过率为305 +/- 35微升/min/100g体重(p < 0.05)。联合治疗提供的确切保护机制尚不清楚，但这种方法可能有助于保护肾脏免受缺血性损伤。

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The effects of d-propranolol and captopril on post-ischaemic acute renal failure in rats.

The effect of the combined therapy of d-propranolol and captopril was evaluated in post-ischaemic acute renal failure in rats. The glomerular filtration rate measured 24 hours after ischaemic insult in the animals receiving no drugs was 54 +/- 11 microliter/min/100g body weight while in animals treated with the combination of d-propranolol and captopril it was 305 +/- 35 microliter/min/100g body weight (p less than 0.05). The precise mechanism of protection afforded by the combination therapy is not clear, but this approach could be useful in protecting the kidney from ischaemic damage.

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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