受损脊髓的脂质水解和过氧化:甲基强的松龙或维生素E和硒的部分保护作用。

D K Anderson, R D Saunders, P Demediuk, L L Dugan, J M Braughler, E D Hall, E D Means, L A Horrocks
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引用次数: 201

摘要

猫脊髓压缩性创伤导致细胞膜脂质代谢发生非常迅速的改变,包括脂质水解,释放花生四烯酸等脂肪酸,产生生物活性类二十烷,以及胆固醇的损失。这种对细胞膜的干扰可直接损害细胞,并可导致继发的组织离子失衡、缺血、水肿和神经噬噬性炎症。用合成糖皮质激素甲基强的松龙琥珀酸钠(MPSS)或抗氧化剂维生素E和硒(Se)进行预处理,完全阻止了胆固醇的损失,部分抑制了脂肪分解和前列腺素的产生。MPSS治疗可显著减少损伤后组织坏死和瘫痪。初步证据表明,维生素E和硒预处理对脊髓损伤(SCI)也有保护作用。我们推测,这些药物在脊髓损伤后保持功能的能力,可能部分地存在于它们限制创伤引起的脂质代谢变化的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium.

Compression trauma of the cat spinal cord induces a very rapid alteration in the lipid metabolism of cellular membranes, including lipid hydrolysis with release of fatty acids including arachidonate, production of biologically active eicosanoids, and loss of cholesterol. This disturbance of cellular membranes can directly damage cells and can lead to the secondary development of tissue ionic imbalance, ischemia, edema, and inflammation with neuronophagia. Pretreatment with either the synthetic glucocorticoid methylprednisolone sodium succinate (MPSS) or the antioxidants vitamin E and selenium (Se) completely prevented the loss of cholesterol and partially inhibited lipolysis and prostanoid production. Treatment with MPSS significantly reduced the postinjury tissue necrosis and paralysis. Preliminary evidence indicates that pretreatment with vitamin E and Se also protected against the effects of spinal cord injury (SCI). We speculate that the ability of these agents to preserve function after SCI may, in part, reside in their capacity to limit the trauma-induced changes in lipid metabolism.

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