光诱导电荷转移复合物介导的脱羧磷酸化

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-20 DOI:10.1021/acs.orglett.6c04068

Hailong He,Jiajin Chen,Hongyao Wang,Wenlong He,Tao Zhou,Zihao Chen,Zhiyan Xue,Qilong Wu,Ziyi Xu,Shuyang Liu,Yunhe Jin

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引用次数: 0

摘要

磷盐是有机合成中有价值的中间体，但其制备往往需要苛刻的条件和特定的碳前体。本文报道了一种光诱导氧化还原活性酯（RAEs）脱羧磷酸化反应，用于直接合成烷基和苄基磷盐。由NaI、叔膦和RAEs形成的光响应性三元电荷转移配合物（CTC）可以在过渡金属和无外部光催化剂的条件下进行反应。该方法可耐受多种苯基和脂肪族rae和叔膦，包括商业膦配体框架，并可实现复合羧酸衍生底物的后期膦化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photoinduced Charge-Transfer Complex-Mediated Decarboxylative Phosphoniumation

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Photoinduced Charge-Transfer Complex-Mediated Decarboxylative Phosphoniumation

Phosphonium salts are valuable intermediates in organic synthesis, but their preparation often requires harsh conditions and specific carbon precursors. Herein, we report a photoinduced decarboxylative phosphoniumation of redox-active esters (RAEs) for the direct synthesis of alkyl and benzyl phosphonium salts. A photoresponsive ternary charge-transfer complex (CTC) formed from NaI, tertiary phosphines, and RAEs enables the reaction under transition-metal- and external-photocatalyst-free conditions. The method tolerates diverse benzyl and aliphatic RAEs and tertiary phosphines, including commercial phosphine ligand frameworks, and enables the late-stage phosphoniumation of complex carboxylic-acid-derived substrates.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.