TfOH/HFIP簇促进异构C-C键的断裂和重构

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-20 DOI:10.1021/acs.orglett.6c04105

Yilin Xing,Xinyu Song,Yuanyuan Liu,Wanting Fu,Xuannai Wang,Yuanli Ding,Zikun Wang

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引用次数: 0

摘要

羧酸的C-C键裂解和重建主要是在C-C (O)位置进行的。在此，我们成功地开发了一种TfOH/HFIP簇促进的分散策略，用于烷基酸的C-C键切割和随后与芳烃的重建，通过可调的脱羧或脱酮化提供了选择性的不同分子结构。该平台不仅促进了温和的脱羧功能化，而且为羧酸建立了前所未有的脱酮功能化途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

TfOH/HFIP Cluster-Promoted Divergent C–C Bond Cleavage and Reconstruction of Alkynoic Acids

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TfOH/HFIP Cluster-Promoted Divergent C–C Bond Cleavage and Reconstruction of Alkynoic Acids

C–C bond cleavage and reconstruction of carboxylic acids is predominantly directed at the C–C(O) position. Herein, we have successfully developed a TfOH/HFIP cluster-promoted divergent strategy for the C–C bond cleavage of alkynoic acids and their subsequent reconstruction with arenes, affording selective access to distinct molecular architectures through tunable decarboxylation or deketonation. This platform not only facilitates mild decarboxylative functionalization but also establishes an unprecedented deketonative functionalization pathway for carboxylic acids.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.