乙烯磺酸是一种用于磺胺乙烯化的非常规乙烯基前体

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-17 DOI:10.1021/acs.orglett.6c04283

Nan Wang,Shaowu Zhu,You Zi

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引用次数: 0

摘要

摘要报道了一种以硫酸乙酯为前驱体的无过渡金属亚砜酰化反应。该反应可直接获得结构多样的乙烯基亚胺，而无需预功能化的乙烯基试剂。该方法具有广泛的底物范围，可耐受各种卤素、烷基、烷氧基和杂芳基取代基，以及不同的n -保护基团和s -烷基取代基。该转化在温和的条件下进行，易于应用于制备规模的合成。

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Ethylene Sulfate as an Unconventional Vinyl Precursor for Sulfenamide Vinylation

Abstract A transition-metal-free vinylation of sulfenamides using ethylene sulfate as an unconventional vinyl precursor is reported. The reaction provides direct access to structurally diverse vinyl sulfilimines without prefunctionalized vinyl reagents. The method exhibits a broad substrate scope, tolerating diverse halogen, alkyl, alkoxy, and heteroaryl substituents, as well as different N-protecting groups and S-alkyl substituents. The transformation proceeds under mild conditions and is readily applicable to preparative-scale synthesis.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.