[3+2] aldinoboranes与N -酰基吡唑的环加成

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2026-10-15 DOI:10.1021/acs.orglett.6c04005

Min Liu,Tongdao Wang

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引用次数: 0

摘要

摘要：成功地实现了aldioboranes与n -酰基吡唑之间的[3+2]环加成反应。用Piers硼烷HB(C6F5)2在原位直接硼化制备了Aldiminoboranes，作为C = N = B的构建块。[3+2]环加成提供了五元bn杂环化合物，并具有显著的酰基迁移特征。此外，该反应对腈和n -酰基吡唑的底物范围很广，分离产物的产率为56-87%。

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[3+2] Cycloadditions of Aldiminoboranes with N -Acylpyrazoles

Abstract The [3+2] cycloaddition between aldiminoboranes and N-acylpyrazoles was successfully achieved. Aldiminoboranes, serving as C═N═B building blocks, were generated in situ via direct hydroboration of nitriles with Piers’ borane HB(C6F5)2. The [3+2] cycloaddition furnishes five-membered BN-heterocyclic compounds and notably features an acyl migration. Furthermore, the reaction exhibits a broad substrate scope with respect to both nitriles and N-acylpyrazoles, affording the target products in 56–87% isolated yields.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.