灵长类动物第一体感区身体中线表征的双侧感受野和胼胝体连通性。

F Conti, M Fabri, T Manzoni
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引用次数: 55

摘要

为了研究猕猴中枢后皮层3b区和1区躯干表征区的感受野组织和胼胝体连通性,进行了实验研究。多单元微电极记录显示,对横跨身体中线的双侧RFs触觉刺激作出反应的神经元包含在主干图的三个地形不同的区域。在一个区域,在细胞结构区3b和1之间的交界处,RFs横跨躯干的背中线。在另外两个区,一个位于中央后窝前的尾侧1区,另一个位于中央沟后岸深处的背侧3b区,rf横跨躯干腹中线。第一个和另外两个区域在这里分别被称为背侧和腹侧中线表征区。在主干图的其他地方,神经元只对对侧射频刺激有反应。利用辣根过氧化物酶(HRP)的转运,研究了辣根主干图胼胝体的连通性。在电生理学上确定的一个半球主干表征部位多次注射HRP,标记对侧同位皮层的胼胝体纤维末梢和胼胝体突起神经元。密集的胼胝体神经元斑块被HRP强烈标记,分布在代表身体中线的皮质区域,大部分分布在第三层。一些被HRP轻度标记的神经元分散在主干图的其他区域。胼胝体末端在中线区域最密集,而在侧干区域非常稀疏或无。单独或从同一动物获得的生理和解剖学数据的相关性表明,含有双侧野神经元的皮质区域也含有最高密度的标记胼胝体终端和神经元。这种相关性表明,胼胝体在身体中线的感知中发挥了作用,要么是通过产生这些神经元的双侧射频,要么是通过协调含有丘脑产生双侧射频的神经元区域的活动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bilateral receptive fields and callosal connectivity of the body midline representation in the first somatosensory area of primates.

Experiments were performed in order to study the receptive field (RF) organization and the callosal connectivity of the trunk representation zone in areas 3b and 1 of the postcentral cortex of macaque monkeys. Multiunit microelectrode recordings showed that neurons responding to tactile stimulation of bilateral RFs across the midline of the body were contained in three topographically distinct zones of the trunk map. In one zone, at the junction between cytoarchitectonic areas 3b and 1, RFs straddled the dorsal midline of the trunk. In the other two zones, one located caudally in area 1 in front of the postcentral dimple, and the other rostrally in area 3b in the depth of the posterior bank of the central sulcus, RFs straddled the ventral midline of the trunk. The first one and the other two zones are referred to here as the dorsal and the ventral midline representation zones, respectively. Elsewhere in the trunk map, neurons responded only to stimulation of contralateral RFs. The callosal connectivity of the trunk map was studied by means of the transport of horseradish peroxidase (HRP). Multiple injections of HRP in electrophysiologically identified sites of the trunk representation in one hemisphere labeled both callosal fiber terminals and callosally projecting neurons in the contralateral homotopic cortex. Dense patches of callosal neurons intensely labeled with HRP were present in the cortical regions representing the body midlines and were distributed for the most part in layer III. Some neurons lightly labeled with HRP were scattered in other zones of the trunk map. Callosal terminations were densest within the midline zones and very sparse or absent in the lateral trunk zones. Correlation of physiological and anatomical data obtained either separately or from the same animal demonstrated that cortical regions containing bilateral-field neurons also contained the highest density of labeled callosal terminations and neurons. This correlation suggests a role for the corpus callosum in the perception of the body midline, either by generating the bilateral RFs of these neurons or by coordinating the activity of the regions containing neurons with thalamically generated bilateral RFs.

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