2095-P：与青少年和年轻人2型糖尿病相关的产妇社会人口学、孕前和妊娠因素：木瓜研究

IF 9.3 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2026-06-11 DOI:10.2337/db26-2095-p

SAHER DAREDIA, SARA AGHAEE, JULIA ACKER, JENNIFER Y. LIU, CINDY J. HUANG, ANDREW KARTER, AI KUBO, JULIANNA DEARDORFF

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引用次数: 0

摘要

简介和目的：全球青少年2型糖尿病（T2D）发病率上升。孕前和妊娠期是后期T2D风险的敏感期，但影响暴露的因素尚不清楚。我们在Kaiser Permanente北加州（KPNC）的青少年和年轻人不良心脏代谢问题预测因子（PAPAYA）研究中研究了孕产妇和妊娠因素与早发性T2D之间的关系。方法：该回顾性队列包括2003-2011年在KPNC出生的303037人。从电子健康记录和出生证明中获取孕产妇（教育程度、年龄、胎次、医疗补助状况、孕前BMI和糖尿病）和妊娠（妊娠糖尿病、先兆子痫、早产、分娩方式）因素。早发性T2D（年龄10-21岁；N=453）通过KPNC糖尿病登记处确诊。Cox比例风险模型估计了混杂因素调整后的风险比。结果：队列中48.8%为女性，种族多样化（白人37.7%，西班牙裔25.5%，亚洲/太平洋岛民19.6%，黑人7.0%，美洲原住民0.3%，其他9.9%）。除早产和分娩方式外，所有模型的关联都很显著，孕前BMI和糖尿病的影响估计最强（见表）。结论：母亲的社会人口学、孕前和孕期因素与早发性T2D相关，为早期干预提供了目标。S. Daredia：没有。S. Aghaee：没有。阿克尔：没有。J.Y. Liu：没有。C.J.黄：没有。A.卡特：研究支持；当前的;, Dexcom公司将公司。久保：没有。J. Deardorff：没有。资助国家心肺血液研究所（1R01HL177516-01）；国家糖尿病、消化和肾脏疾病研究所（1r01dk13916 - 01a1）

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2095-P: Maternal Sociodemographic, Prepregnancy, and Pregnancy Factors Associated with Type 2 Diabetes in Adolescents and Young Adults: The PAPAYA Study

Introduction and Objective: Youth type 2 diabetes (T2D) rates have risen globally. Preconception and pregnancy are sensitive periods for later T2D risk, yet contributing exposures remain unclear. We examined associations between maternal and pregnancy factors and early-onset T2D in the Predictors of Adverse Cardiometabolic Problems in Adolescents and Young Adults (PAPAYA) study at Kaiser Permanente Northern California (KPNC). Methods: This retrospective cohort included 303,037 individuals born at KPNC in 2003-2011. Maternal (education, age, parity, Medicaid status, pre-pregnancy BMI and diabetes) and pregnancy (gestational diabetes, preeclampsia, preterm birth, delivery mode) factors were obtained from electronic health records and birth certificates. Early-onset T2D (ages 10-21; N=453) was identified via the KPNC Diabetes Registry. Cox proportional hazards models estimated hazard ratios adjusting for confounders. Results: The cohort was 48.8% female and racially diverse (37.7% White, 25.5% Hispanic, 19.6% Asian/Pacific Islander, 7.0% Black, 0.3% Native American, 9.9% Other). Associations were significant in all models except preterm birth and delivery mode, with strongest effect estimates for pre-pregnancy BMI and diabetes (see Table). Conclusion: Several maternal sociodemographic, pre-pregnancy, and pregnancy factors were associated with early-onset T2D, providing targets for early-life interventions. Disclosure S. Daredia: None. S. Aghaee: None. J. Acker: None. J.Y. Liu: None. C.J. Huang: None. A. Karter: Research Support; Current; Dexcom, Inc. A. Kubo: None. J. Deardorff: None. Funding National Heart Lung and Blood Institute (1R01HL177516-01); National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK139116-01A1)

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.