[治疗效果与血液中药物浓度关系的问题]。

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology Pub Date : 1987-07-01

M G Glezer, S V Iakovlev, L E Kholodov

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引用次数: 0

摘要

从疗效实现机制和临床试验结果出发，探讨了药物浓度-反应关系分析的若干途径。这些研究的实例包括利尿剂浓度-反应关系的定量分析模型，以及最大限度原则的临床试验结果，该原则提供了药物在血液中的稳态水平的预测和药物效果的估计。

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[Problems of the relationship of the therapeutic effect and the concentration of drugs in the blood].

Certain approaches to analysis of the drug concentration-response relationship based on the mechanism of the effect realization and the results of their clinical trials are discussed. The studies are exemplified by a model for quantitative analysis of the concentration-response relationship developed for diuretics and by the results of the clinical trial of the principle of the maximum providing prediction of the steady-state level of the drugs in blood and estimation of the drug effect.

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Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology

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