Wies Claeys, Kristof Baete, Laurence Beels, Claire Bernard, Rachele Danieli, Yves D'Asseler, An De Crop, Michel Hesse, Victor Nuttens, Bruno Vanderlinden, Michel Koole
{"title":"放射性核素校准器与SPECT/CT方法在临床定量177Lu成像中的多中心比较","authors":"Wies Claeys, Kristof Baete, Laurence Beels, Claire Bernard, Rachele Danieli, Yves D'Asseler, An De Crop, Michel Hesse, Victor Nuttens, Bruno Vanderlinden, Michel Koole","doi":"10.1186/s40658-026-00877-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Following the clinical success of [Formula: see text]-based therapies for neuroendocrine tumors and prostate cancer, accurate quantification of [Formula: see text] using radionuclide calibrators (RNCs) and SPECT/CT is gaining importance as prerequisite for accurate treatment delivery and dosimetry. However, the lack of standardization can introduce inter-system variability, compromising multi-center clinical trials. This study aimed to assess the accuracy and variability of [Formula: see text] measurements using RNCs and SPECT/CT across different systems and hospitals.</p><p><strong>Methods: </strong>A uniform cylindrical phantom and a NEMA phantom with hot spheres were prepared using traceable activities and imaged at 8 different hospitals using 13 SPECT/CT systems (9 conventional and 4 3D CZT). Acquisitions and reconstructions were performed using both site-specific and standardized protocols. The cylindrical phantom images were used to evaluate the system calibration and establish image calibration factors (ICFs), the NEMA images to evaluate effective resolution by calculating recovery coefficients (RCs). In parallel, two vials were measured to test RNC accuracy.</p><p><strong>Results: </strong>RNC measurements differed up to 11% between centers, while SPECT quantification of the cylindrical phantom differed up to 20%. While ICFs were consistent for systems of the same type, image quality varied strongly when using clinical protocols (36% difference in RCs in the largest sphere). Standardized reconstruction reduced variability in RCs for each system type (maximum 12% difference), regardless of acquisition protocol, but differences between system types persisted when standardizing acquisition and reconstruction (33% difference).</p><p><strong>Conclusion: </strong>Current [Formula: see text] measurement practices yield significant variability in quantification and image quality. Harmonization efforts should prioritize standardized calibration and reconstruction protocols to improve multicenter reproducibility of quantitative [Formula: see text]-SPECT/CT.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multicenter comparison of radionuclide calibrators and SPECT/CT protocols for quantitative <sup>177</sup>Lu imaging in clinical practice.\",\"authors\":\"Wies Claeys, Kristof Baete, Laurence Beels, Claire Bernard, Rachele Danieli, Yves D'Asseler, An De Crop, Michel Hesse, Victor Nuttens, Bruno Vanderlinden, Michel Koole\",\"doi\":\"10.1186/s40658-026-00877-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Following the clinical success of [Formula: see text]-based therapies for neuroendocrine tumors and prostate cancer, accurate quantification of [Formula: see text] using radionuclide calibrators (RNCs) and SPECT/CT is gaining importance as prerequisite for accurate treatment delivery and dosimetry. However, the lack of standardization can introduce inter-system variability, compromising multi-center clinical trials. This study aimed to assess the accuracy and variability of [Formula: see text] measurements using RNCs and SPECT/CT across different systems and hospitals.</p><p><strong>Methods: </strong>A uniform cylindrical phantom and a NEMA phantom with hot spheres were prepared using traceable activities and imaged at 8 different hospitals using 13 SPECT/CT systems (9 conventional and 4 3D CZT). Acquisitions and reconstructions were performed using both site-specific and standardized protocols. The cylindrical phantom images were used to evaluate the system calibration and establish image calibration factors (ICFs), the NEMA images to evaluate effective resolution by calculating recovery coefficients (RCs). In parallel, two vials were measured to test RNC accuracy.</p><p><strong>Results: </strong>RNC measurements differed up to 11% between centers, while SPECT quantification of the cylindrical phantom differed up to 20%. While ICFs were consistent for systems of the same type, image quality varied strongly when using clinical protocols (36% difference in RCs in the largest sphere). Standardized reconstruction reduced variability in RCs for each system type (maximum 12% difference), regardless of acquisition protocol, but differences between system types persisted when standardizing acquisition and reconstruction (33% difference).</p><p><strong>Conclusion: </strong>Current [Formula: see text] measurement practices yield significant variability in quantification and image quality. Harmonization efforts should prioritize standardized calibration and reconstruction protocols to improve multicenter reproducibility of quantitative [Formula: see text]-SPECT/CT.</p>\",\"PeriodicalId\":11559,\"journal\":{\"name\":\"EJNMMI Physics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2026-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s40658-026-00877-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s40658-026-00877-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Multicenter comparison of radionuclide calibrators and SPECT/CT protocols for quantitative 177Lu imaging in clinical practice.
Purpose: Following the clinical success of [Formula: see text]-based therapies for neuroendocrine tumors and prostate cancer, accurate quantification of [Formula: see text] using radionuclide calibrators (RNCs) and SPECT/CT is gaining importance as prerequisite for accurate treatment delivery and dosimetry. However, the lack of standardization can introduce inter-system variability, compromising multi-center clinical trials. This study aimed to assess the accuracy and variability of [Formula: see text] measurements using RNCs and SPECT/CT across different systems and hospitals.
Methods: A uniform cylindrical phantom and a NEMA phantom with hot spheres were prepared using traceable activities and imaged at 8 different hospitals using 13 SPECT/CT systems (9 conventional and 4 3D CZT). Acquisitions and reconstructions were performed using both site-specific and standardized protocols. The cylindrical phantom images were used to evaluate the system calibration and establish image calibration factors (ICFs), the NEMA images to evaluate effective resolution by calculating recovery coefficients (RCs). In parallel, two vials were measured to test RNC accuracy.
Results: RNC measurements differed up to 11% between centers, while SPECT quantification of the cylindrical phantom differed up to 20%. While ICFs were consistent for systems of the same type, image quality varied strongly when using clinical protocols (36% difference in RCs in the largest sphere). Standardized reconstruction reduced variability in RCs for each system type (maximum 12% difference), regardless of acquisition protocol, but differences between system types persisted when standardizing acquisition and reconstruction (33% difference).
Conclusion: Current [Formula: see text] measurement practices yield significant variability in quantification and image quality. Harmonization efforts should prioritize standardized calibration and reconstruction protocols to improve multicenter reproducibility of quantitative [Formula: see text]-SPECT/CT.
期刊介绍：
EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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