{"title":"磷化铝中毒的心电图、超声心动图和心脏生物标志物及其预后相关性研究。","authors":"Harshvardhan Tiwari, Deepti Sharma, Meenaxi Sharda, Dinesh Bishnoi, Harshit Garg","doi":"10.59556/japi.74.1415","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aluminum phosphide (AlP) poisoning is a medical emergency with an alarmingly high mortality rate, primarily due to its rapid cardiotoxic effects.</p><p><strong>Objective: </strong>To identify and evaluate key prognostic indicators-clinical, electrocardiographic, echocardiographic, and biochemical-in patients with AlP poisoning.</p><p><strong>Materials and methods: </strong>A cross-sectional observational study was conducted on 100 patients with confirmed AlP ingestion. ECG changes, cardiac biomarkers (troponin-I, CPK-MB, LDH, and CPK-NAC), 2D echocardiography findings, and acid-base disturbances were analyzed in relation to survival outcomes.</p><p><strong>Results: </strong>ECG abnormalities and decreased ejection fraction were significantly associated with mortality. Elevated cardiac biomarkers and profound acidosis were strong independent predictors of poor prognosis.</p><p><strong>Conclusion: </strong>AlP poisoning causes critical cardiovascular compromise. Early identification of high-risk patients may guide aggressive intervention and resource allocation in intensive care settings.</p>","PeriodicalId":22693,"journal":{"name":"The Journal of the Association of Physicians of India","volume":"74 4","pages":"50-53"},"PeriodicalIF":0.0000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Study on Electrocardiography Echocardiography and Cardiac Biomarkers in Aluminium Phosphide Poisoning and Their Prognostic Correlation.\",\"authors\":\"Harshvardhan Tiwari, Deepti Sharma, Meenaxi Sharda, Dinesh Bishnoi, Harshit Garg\",\"doi\":\"10.59556/japi.74.1415\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Aluminum phosphide (AlP) poisoning is a medical emergency with an alarmingly high mortality rate, primarily due to its rapid cardiotoxic effects.</p><p><strong>Objective: </strong>To identify and evaluate key prognostic indicators-clinical, electrocardiographic, echocardiographic, and biochemical-in patients with AlP poisoning.</p><p><strong>Materials and methods: </strong>A cross-sectional observational study was conducted on 100 patients with confirmed AlP ingestion. ECG changes, cardiac biomarkers (troponin-I, CPK-MB, LDH, and CPK-NAC), 2D echocardiography findings, and acid-base disturbances were analyzed in relation to survival outcomes.</p><p><strong>Results: </strong>ECG abnormalities and decreased ejection fraction were significantly associated with mortality. Elevated cardiac biomarkers and profound acidosis were strong independent predictors of poor prognosis.</p><p><strong>Conclusion: </strong>AlP poisoning causes critical cardiovascular compromise. Early identification of high-risk patients may guide aggressive intervention and resource allocation in intensive care settings.</p>\",\"PeriodicalId\":22693,\"journal\":{\"name\":\"The Journal of the Association of Physicians of India\",\"volume\":\"74 4\",\"pages\":\"50-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2026-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of the Association of Physicians of India\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.59556/japi.74.1415\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of the Association of Physicians of India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.59556/japi.74.1415","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
A Study on Electrocardiography Echocardiography and Cardiac Biomarkers in Aluminium Phosphide Poisoning and Their Prognostic Correlation.
Background: Aluminum phosphide (AlP) poisoning is a medical emergency with an alarmingly high mortality rate, primarily due to its rapid cardiotoxic effects.
Objective: To identify and evaluate key prognostic indicators-clinical, electrocardiographic, echocardiographic, and biochemical-in patients with AlP poisoning.
Materials and methods: A cross-sectional observational study was conducted on 100 patients with confirmed AlP ingestion. ECG changes, cardiac biomarkers (troponin-I, CPK-MB, LDH, and CPK-NAC), 2D echocardiography findings, and acid-base disturbances were analyzed in relation to survival outcomes.
Results: ECG abnormalities and decreased ejection fraction were significantly associated with mortality. Elevated cardiac biomarkers and profound acidosis were strong independent predictors of poor prognosis.
Conclusion: AlP poisoning causes critical cardiovascular compromise. Early identification of high-risk patients may guide aggressive intervention and resource allocation in intensive care settings.
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