{"title":"磷霉素治疗耐甲氧西林金黄色葡萄球菌败血症的体内外研究。","authors":"W Y Lau, C H Teoh-Chan, S T Fan, K F Lau","doi":"10.1017/s0022172400066183","DOIUrl":null,"url":null,"abstract":"<p><p>Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.</p>","PeriodicalId":15931,"journal":{"name":"Journal of Hygiene","volume":"96 3","pages":"419-23"},"PeriodicalIF":0.0000,"publicationDate":"1986-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s0022172400066183","citationCount":"11","resultStr":"{\"title\":\"In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.\",\"authors\":\"W Y Lau, C H Teoh-Chan, S T Fan, K F Lau\",\"doi\":\"10.1017/s0022172400066183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.</p>\",\"PeriodicalId\":15931,\"journal\":{\"name\":\"Journal of Hygiene\",\"volume\":\"96 3\",\"pages\":\"419-23\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1017/s0022172400066183\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hygiene\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/s0022172400066183\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hygiene","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/s0022172400066183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.
Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.
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