Immunohistochemical Investigation of Prostaglandin E2 During the Healing of Experimentally Gastric Ulceration in Rats

Abstract The current study attempt to identify the healing activities of esomeprazole, curcumin, chitosan as well as mixture from curcumin and chitosan on gastric ulceration induced by ethanol in female rats. this study included 30 rats, their average weight ranged between (195.600-198.600 gm) separated into 2 control groups and 4 treated groups each group contained 5 rats. all groups treated for 5 days after last dose from ethanol. After the experiment has been over, the body was weighed before and after the end of the experiment. The therapeutic effects of esomeprazole, chitosan, curcumin and mixture were identified by comparing the volume and pH of gastric juice, ulcer index as well as curative index. The results of the current study showed that percentage change in body weight means decreased significantly in treated group with curcumin compared to the positive control group. While in the case of the esomeprazole, chitosan and mixture there was no significant change compared with the positive control group. In addition, the results indicated a significant decreased in the ulcer index values and volume of gastric juice in esomeprazole, curcumin, chitosan and mixture in comparison with the positive control group. By comparing the immunohistochemical investigation of the PGE2 expressions in gastric tissue, the development of gastric ulcers was analyzed.