我们是否找到了体外细胞毒性试验的相关参数?

Molecular toxicology Pub Date : 1987-09-01
C A Reinhardt
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引用次数: 0

摘要

根据需要达到的目标和体外试验的能力,简要审查了目前设计细胞毒性试验的战略,以满足公众对动物试验替代方法的高度期望。选择用于评估局部毒性和神经毒性的各种细胞毒性试验和参数作为例子,并讨论了它们的相关性。过去体外和短期诱变试验的经验表明,不要寻找单一的超级试验。关于合理的安全性测试的建议意味着必须开发一种综合方法,将一系列细胞测试和结构-活性分析以及动力学和代谢研究的结果结合起来。这种综合办法的相关性必须直接针对可能暴露的生物体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Do we find relevant parameters for in vitro cytotoxicity testing?

The current strategy for the design of cytotoxicity tests is briefly reviewed in light of goals that need to be reached, and in the capacity of in vitro tests to fulfill the high public expectations for alternative methods to animal testing. Various cytotoxicity tests and parameters used for the assessment of topical toxicity and of neurotoxicity are chosen as examples and their relevance is discussed. Past experience with in vitro and short-term tests for mutagenicity shows not to look for one single supertest. A proposition for reasonable safety testing implies that a combined approach must be developed that integrates the results from a battery of cell tests and from structure-activity analyses as well as from kinetic and metabolic studies. The relevance of such an integrated approach must be aimed directly at the organisms that may be exposed.

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