COVID-19大流行对实体恶性肿瘤和骨转移患者的社会心理影响（PsyCO-B）：一项多中心前瞻性观察研究

IF 3.5 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI:10.1016/j.jbo.2026.100744

Paolo Taurisano , Ester Cornacchia , Maria Fara De Caro , Vittorio Fusco , Toni Ibrahim , Anna Ragno , Francesco Salonne , Giulia Paparella , Marta Betti , Serena Penpa , Maura Rossi , Rossella Hakim , Michela Pierini , Camillo Porta , Stella D’Oronzo

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引用次数: 0

摘要

背景：COVID-19大流行极大地改变了我们的日常习惯。癌症患者，特别是骨转移患者，由于他们的临床状况和社会距离，是最受关注的人群之一。目的：本研究旨在探讨大流行对BM患者的心理社会影响，调查临床严重程度、心理症状、应对策略和感知创伤影响的作用。方法：对三家机构的BM患者进行6份问卷调查：医院焦虑抑郁量表、WHO生活质量量表、寻求专业心理帮助的态度、简易疾病感知问卷、简易COPE问卷和影响事件量表-修订版（IES-R）。收集临床、病理和社会人口学数据，并使用描述性统计进行分析。临床严重程度通过应用特定的预后模型来估计。统计分析包括相关性、线性回归和中介分析。结果：临床严重程度与抑郁症状显著相关，而COVID-19大流行的感知创伤影响与焦虑、特定应对策略（社会支持、回避和宗教信仰）的使用以及对心理支持的更开放程度密切相关。中介分析表明，IES-R在主观疾病知觉与焦虑之间起中介作用。结论：在大流行期间，BM患者的抑郁症状主要与其特定的临床状况有关，而与焦虑相关的症状主要与大流行相关的创伤经历有关。无论疾病的严重程度如何，大流行病的心理影响都影响到应对战略和支持请求。这些发现强调了关注患者经验和临床状况的心理肿瘤支持的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Psychosocial impact of COVID-19 pandemic on patients with solid malignancies and bone metastases (PsyCO-B): a multicentre prospective observational study

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Psychosocial impact of COVID-19 pandemic on patients with solid malignancies and bone metastases (PsyCO-B): a multicentre prospective observational study

Background

COVID-19 pandemic dramatically changed our daily habits. Patients with cancer, particularly those with bone metastases (BM), were among the most concerned individuals, due to both their clinical condition and social distancing.

Objectives

This study aimed to explore psychosocial effects of the pandemic on patients with BM, investigating the role of clinical severity, psychological symptoms, coping strategies, and perceived traumatic impact.

Methods

Six questionnaires were administered to patients with BM from three Institutions: Hospital Anxiety-Depression Scale, WHO Quality of Life-BREF, Attitude Toward Seeking Professional Psychological Help, Brief Illness Perception Questionnaire, Brief COPE, and Impact Event Scale-Revised (IES-R). Clinical, pathological, and socio-demographic data were collected and analyzed using descriptive statistics. Clinical severity was estimated by applying a specific prognostic model. Statistical analyses included correlations, linear regressions and mediation analyses.

Results

Clinical severity was significantly associated with depressive symptoms whereas the perceived traumatic impact of the COVID-19 pandemic was strongly associated with anxiety, the use of specific coping strategies (social support, avoidance and religiosity) and greater openness to psychological support. Mediation analysis showed that the IES-R mediates the relationship between subjective perception of illness and anxiety.

Conclusions

During the pandemic, depressive symptoms in patients with BM were mainly related to their specific clinical condition, whereas those associated with anxiety were mostly due to the experience of pandemic-associated trauma. The psychological impact of the pandemic influenced coping strategies and the request for support, regardless of the disease severity. These findings highlight the importance of psycho-oncological support focused on the patient’s experience and clinical condition.

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.