头孢替坦β -内酰胺酶稳定性及体外活性研究其他8种β -内酰胺类抗生素与庆大霉素的比较。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology Pub Date : 1986-08-01 DOI:10.1111/j.1699-0463.1986.tb03049.x

H Friis, J Prag, E Togsverd, M W Benzon

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引用次数: 1

摘要

研究了头孢替坦等8种β -内酰胺类抗生素和庆大霉素对288株新分离细菌的体外抑菌活性。头孢替坦的活性普遍高于2。代头孢菌素比头孢呋辛低3倍。测试了一代头孢菌素。此外，头孢替坦对厌氧菌有一定的抗菌活性。头孢替坦是一种头孢霉素，发现对所有14种质粒介导和2种染色体介导的β -内酰胺酶具有耐药性。头孢替坦具有β -内酰胺酶耐药性和抗菌活性，似乎是“第二代”头孢菌素，几乎与3。代头孢菌素对肠杆菌科细菌的抑菌活性。

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The beta-lactamase stability and in vitro activity of cefotetan; a comparison with 8 other beta-lactam antibiotics and gentamicin.

The antibacterial activity of cefotetan, 8 other beta-lactam antibiotics and gentamicin, was tested in vitro on 288 recently isolated bacteria. The activity of cefotetan was generally higher than the 2.generation cephalosporin cefuroxime and lower than the 3.generation cephalosporins tested. In addition, cefotetan was shown to have some antibacterial activity against anaerobic bacteria. Cefotetan is a cephamycin and was found resistant to all 14 plasmid-mediated and 2 chromosomally-mediated beta-lactamases. With its beta-lactamase resistance and antibacterial activity, cefotetan seems to be a "second-generation-like" cephalosporin, almost with 3.generation cephalosporin antibacterial activity against Enterobacteriaceae.

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Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology

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