{"title":"遗传分析研讨会四:11p的两点和多点作图综述。","authors":"D A Meyers, T H Beaty","doi":"10.1002/gepi.1370030716","DOIUrl":null,"url":null,"abstract":"The seven loci: insulin (INS), oncogene c-Ha-ras-1 (HRASl), ADJ (DllS12) , D-globin (HBBC) , parathyroid hormone (PTH) , calcitonin (CALC1) and catalase (CAT) have all been assigned to the short arm of chromosome 11 (Human Gene Mapping Workshop 8). Results from 2-point linkage analysis using DNA polymorphisms for these loci gave the linkage map: centromere: CAT CALCl PTH HBBC DllS12 (HRAS1: INS). The HBBC and DllS12 loci are relatively tightly linked to the HRASl and INS loci. Because the HRASl and INS loci are tightly linked (only a few cM apart), it had not been possible to order them definitively in previous linkage studies (Antonarakis et al., 1983; Fearon et al., 1984; Kittur et al., 1985; White et al., 1985).","PeriodicalId":77852,"journal":{"name":"Genetic epidemiology. Supplement","volume":"1 ","pages":"99-111"},"PeriodicalIF":0.0000,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/gepi.1370030716","citationCount":"7","resultStr":"{\"title\":\"Genetic analysis workshop IV: summary of two-point and multipoint mapping of 11p.\",\"authors\":\"D A Meyers, T H Beaty\",\"doi\":\"10.1002/gepi.1370030716\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The seven loci: insulin (INS), oncogene c-Ha-ras-1 (HRASl), ADJ (DllS12) , D-globin (HBBC) , parathyroid hormone (PTH) , calcitonin (CALC1) and catalase (CAT) have all been assigned to the short arm of chromosome 11 (Human Gene Mapping Workshop 8). Results from 2-point linkage analysis using DNA polymorphisms for these loci gave the linkage map: centromere: CAT CALCl PTH HBBC DllS12 (HRAS1: INS). The HBBC and DllS12 loci are relatively tightly linked to the HRASl and INS loci. Because the HRASl and INS loci are tightly linked (only a few cM apart), it had not been possible to order them definitively in previous linkage studies (Antonarakis et al., 1983; Fearon et al., 1984; Kittur et al., 1985; White et al., 1985).\",\"PeriodicalId\":77852,\"journal\":{\"name\":\"Genetic epidemiology. Supplement\",\"volume\":\"1 \",\"pages\":\"99-111\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/gepi.1370030716\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genetic epidemiology. Supplement\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/gepi.1370030716\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genetic epidemiology. Supplement","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/gepi.1370030716","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Genetic analysis workshop IV: summary of two-point and multipoint mapping of 11p.
The seven loci: insulin (INS), oncogene c-Ha-ras-1 (HRASl), ADJ (DllS12) , D-globin (HBBC) , parathyroid hormone (PTH) , calcitonin (CALC1) and catalase (CAT) have all been assigned to the short arm of chromosome 11 (Human Gene Mapping Workshop 8). Results from 2-point linkage analysis using DNA polymorphisms for these loci gave the linkage map: centromere: CAT CALCl PTH HBBC DllS12 (HRAS1: INS). The HBBC and DllS12 loci are relatively tightly linked to the HRASl and INS loci. Because the HRASl and INS loci are tightly linked (only a few cM apart), it had not been possible to order them definitively in previous linkage studies (Antonarakis et al., 1983; Fearon et al., 1984; Kittur et al., 1985; White et al., 1985).
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